GNH USA

Europe — EMA

Natterman Melrosum Extra Sterk (Codeine Phosphate Hemihydrate)

GNH USA supplies Natterman Melrosum Extra Sterk (Codeine), an opioid analgesic for mild to moderate pain and cough suppression. Request a quote for supply.

Codeine Phosphate Hemihydrate

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1
Pack/s

What is Codeine Phosphate Hemihydrate?

Codeine phosphate hemihydrate, the active ingredient in Natterman Melrosum Extra Sterk, is an opioid analgesic presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to suppress cough in adult patients when other treatments are insufficient.

GNH USA supplies Natterman Melrosum Extra Sterk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable efficient logistics for global distribution.

What is Codeine Phosphate Hemihydrate used for?

Codeine phosphate hemihydrate acts on the central nervous system to provide opioid analgesia and cough suppression.

- Mild to moderate pain: reduces pain intensity in acute or chronic settings - Cough: suppresses the cough reflex in non‑productive cough - Post‑operative discomfort: alleviates discomfort after minor surgical procedures

What are the side effects of Codeine Phosphate Hemihydrate?

Codeine phosphate hemihydrate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea - Constipation - Drowsiness - Dizziness

Serious or Rare Side Effects: - Respiratory depression - Severe allergic reaction (anaphylaxis) - Dependence or addiction

What precautions apply to Codeine Phosphate Hemihydrate?

When prescribing or dispensing codeine phosphate hemihydrate, several safety considerations are recommended. - Assess pain level: ensure opioid is appropriate for mild to moderate pain - Screen for respiratory disorders: avoid use in severe asthma or COPD - Avoid concurrent CNS depressants: limit use with benzodiazepines or alcohol - Monitor for signs of dependence: observe prolonged use - Store at ambient temperature: keep in original container, protect from moisture and light

What does Codeine Phosphate Hemihydrate interact with?

Codeine phosphate hemihydrate can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Other opioids: additive respiratory depression - Benzodiazepines or barbiturates: enhanced central nervous system depression - Monoamine oxidase inhibitors (MAOIs): risk of serotonin syndrome

Moderate Interactions (Monitor Closely): - CYP2D6 inhibitors (e.g., fluoxetine): may increase codeine levels - Alcohol: may increase sedation and respiratory effects - Anticholinergics: may worsen constipation

Frequently asked questions

What is Natterman Melrosum Extra Sterk used for?+
Natterman Melrosum Extra Sterk contains codeine phosphate hemihydrate and is used to relieve mild to moderate pain and to suppress non‑productive cough in adult patients when other treatments are insufficient.
How does codeine phosphate hemihydrate work?+
After oral administration, codeine is partially metabolised to morphine, which binds to μ‑opioid receptors in the brain and spinal cord. This binding reduces neuronal excitability, decreasing the perception of pain and dampening the cough reflex in the medullary cough centre.
What is the usual dose of Natterman Melrosum Extra Sterk?+
The appropriate dose is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly.
Is Natterman Melrosum Extra Sterk safe in pregnancy or breastfeeding?+
Safety data for codeine use during pregnancy and lactation are limited. Generally, it is avoided unless the benefit outweighs the risk, as it may affect the fetus or infant. Consultation with a healthcare provider is essential before use.
How do I order Natterman Melrosum Extra Sterk from GNH USA?+
Enquiries are submitted via the product page on gnh-usa.com, where you specify the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Natterman Melrosum Extra Sterk compare with other opioid cough suppressants?+
Codeine is a weaker opioid compared with alternatives such as morphine or oxycodone, offering effective pain relief and cough suppression with a lower risk of severe respiratory depression when used at recommended doses. However, it still carries typical opioid risks and may be less potent for severe pain.
What are the storage and handling requirements for this product?+
Store the tablets at ambient temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect from moisture, heat and direct sunlight to maintain product stability.
How is Natterman Melrosum Extra Sterk administered?+
The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can reduce gastrointestinal upset. Follow the prescribing clinician’s instructions for frequency and timing.
What are the most serious risks associated with this medication?+
The most serious risks include respiratory depression, especially in patients with compromised breathing, severe allergic reactions, and the potential for dependence, tolerance and addiction with prolonged use. Immediate medical attention is required if breathing becomes shallow or stops.
Who should not use Natterman Melrosum Extra Sterk?+
Patients with severe respiratory depression, acute asthma attacks, known hypersensitivity to codeine or other opioids, and children under 12 years (unless specifically prescribed) should avoid this medication. It is also contraindicated in individuals taking MAO inhibitors within 14 days.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Codeine Phosphate Hemihydrate
Route
Oral Use
Manufacturer
Vemedia Manufacturing B. V.
Origin
EU

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