Natriumhydrogenkarbonat B. Braun (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogenkarbonat, is a Buffer / alkalinizing agent presented as a solution for injection for intravenous use. It is employed to correct metabolic acidosis and other acid‑base disturbances in hospitalized patients.

GNH USA supplies Natriumhydrogenkarbonat as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The product conforms to EU pharmacopeial standards, is manufactured under strict quality controls, and is available for global distribution with regulatory compliance.

Natriumhydrogenkarbonat is used as an intravenous buffer to manage acid‑base disorders.

Metabolic acidosis: restores normal blood pH by providing bicarbonate ions. Urinary alkalinization: raises urinary pH to facilitate excretion of certain drugs or toxins. Acid‑base disorders: corrects systemic acidemia in critical‑care settings.

Intravenous sodium hydrogen carbonate may be associated with several adverse reactions.

Common Side Effects: - Hypernatremia: elevated serum sodium levels. - Metabolic alkalosis: excessive increase in blood pH. - Local infusion site irritation: pain or erythema at the injection site. - Hypokalemia: reduced serum potassium concentration.

Serious or Rare Side Effects: - Severe metabolic alkalosis leading to respiratory depression. - Cardiac arrhythmias, especially in patients with electrolyte imbalance. - Pulmonary edema due to fluid overload. - Anaphylactic reaction: rare hypersensitivity response.

When using Natriumhydrogenkarbonat, clinicians should observe specific safety measures. - Renal impairment: monitor serum bicarbonate and electrolytes closely. - Cardiac disease: avoid rapid infusion in patients with heart failure. - Fluid overload risk: adjust infusion volume in patients with edema. - Electrolyte monitoring: check potassium and sodium levels during therapy. - Pregnancy and lactation: safety not established; use only if benefit outweighs risk. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Sodium hydrogen carbonate can interact with other medications, requiring attention to dosing and monitoring.

Major Interactions (Avoid): - Concurrent alkalinizing agents (e.g., sodium citrate): may cause severe alkalosis. - Loop diuretics that promote potassium loss: can exacerbate hypokalemia.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may increase risk of hyperkalemia when combined with potassium‑sparing effects. - NSAIDs: can affect renal handling of sodium and bicarbonate. - Calcium channel blockers: monitor blood pressure during rapid infusion. - Antacids containing bicarbonate: additive effect on systemic pH.