GNH USA

Europe — EMA

Natriumhydrogenkarbonat B. Braun (Sodium Hydrogen Carbonate)

GNH USA supplies Natriumhydrogenkarbonat B. Braun (Sodium hydrogen carbonate), a IV solvent/buffer for metabolic acidosis and surgical buffering.

Sodium Hydrogen Carbonate

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What is Sodium Hydrogen Carbonate?

Sodium hydrogen carbonate, the active ingredient in Natriumhydrogenkarbonat B. Braun, is an excipient presented as a sterile solution for intravenous use. It provides bicarbonate ions to buffer blood pH and is employed to correct metabolic acidosis in patients receiving IV therapy.

GNH USA supplies Natriumhydrogenkarbonat B. Braun as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Sodium Hydrogen Carbonate used for?

Natriumhydrogenkarbonat B. Braun is used as an intravenous buffering agent to manage acid‑base disturbances in several clinical settings.

- Metabolic acidosis: restores normal blood pH by supplying bicarbonate ions. - Cardiac surgery: mitigates intra‑operative acidemia and supports hemodynamic stability. - Renal replacement therapy: maintains systemic bicarbonate levels during dialysis procedures.

What are the side effects of Sodium Hydrogen Carbonate?

Adverse reactions may occur with intravenous administration of sodium bicarbonate solutions.

Common Side Effects: - Hypernatremia: elevated serum sodium levels. - Metabolic alkalosis: excessive rise in blood pH. - Hypokalemia: reduced serum potassium concentration. - Fluid overload: increased intravascular volume. - Hypertension: elevated blood pressure due to volume expansion. - Transient erythema at infusion site.

Serious or Rare Side Effects: - Pulmonary edema: accumulation of fluid in the lungs. - Cardiac arrhythmias: irregular heart rhythms associated with electrolyte shifts. - Severe hypervolemia: dangerous fluid overload leading to organ dysfunction. - Cerebral edema: swelling of brain tissue in extreme cases. - Acute kidney injury: impaired renal function from electrolyte disturbances.

What precautions apply to Sodium Hydrogen Carbonate?

Proper clinical assessment and monitoring are essential when using this intravenous buffer.

- Electrolyte monitoring: regularly check serum sodium, potassium, and bicarbonate levels. - Acid‑base assessment: evaluate arterial blood gases before and after infusion. - Renal impairment: adjust dosage or avoid rapid infusion in patients with reduced kidney function. - Cardiac disease: use caution in patients with heart failure or hypertension. - Infusion rate: avoid rapid bolus administration to reduce risk of alkalosis. - Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

What does Sodium Hydrogen Carbonate interact with?

Sodium hydrogen carbonate can influence the activity of several co‑administered drugs.

Major Interactions (Avoid): - Calcium chloride: precipitation risk when mixed in the same solution. - Other alkalinizing agents (e.g., sodium acetate): may cause excessive alkalosis. - Certain antibiotics (e.g., aminoglycosides): reduced efficacy due to altered pH.

Moderate Interactions (Monitor Closely): - Loop diuretics: may exacerbate hypokalemia. - ACE inhibitors or ARBs: increased risk of hyperkalemia when combined with potassium‑sparing effects. - Anticoagulants: pH changes can affect clotting factor activity. - Anticonvulsants (e.g., phenytoin): altered plasma protein binding. - Insulin: may require dose adjustment due to changes in potassium distribution.

Frequently asked questions

What is Natriumhydrogenkarbonat B. Braun used for?+
Natriumhydrogenkarbonat B. Braun is an intravenous sodium bicarbonate solution used to buffer blood pH. It is commonly employed to correct metabolic acidosis, support acid‑base balance during cardiac surgery, and maintain bicarbonate levels in patients undergoing renal replacement therapy.
How does sodium hydrogen carbonate work as a buffer?+
When administered intravenously, sodium hydrogen carbonate dissociates into sodium and bicarbonate ions. The bicarbonate ions combine with excess hydrogen ions in the blood to form carbonic acid, which is then converted to carbon dioxide and water, effectively lowering hydrogen ion concentration and raising blood pH.
What is the usual dose of Natriumhydrogenkarbonat B. Braun?+
The dose of Natriumhydrogenkarbonat B. Braun is determined by the prescribing clinician based on the patient’s acid‑base status, electrolyte levels, and clinical condition. Healthcare professionals calculate the required amount to achieve the desired pH correction.
Is Natriumhydrogenkarbonat B. Braun safe during pregnancy or breastfeeding?+
Safety data for sodium hydrogen carbonate in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and its use should be guided by a qualified healthcare provider.
How do I order Natriumhydrogenkarbonat B. Braun from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does Natriumhydrogenkarbonat B. Braun compare with other buffering agents?+
Compared with other IV buffers such as sodium lactate or acetate solutions, sodium hydrogen carbonate provides a rapid increase in bicarbonate concentration and directly raises blood pH. It is often preferred when immediate correction of acidosis is needed, though clinicians must monitor for potential electrolyte shifts.
What are the storage and handling requirements for Natriumhydrogenkarbonat B. Braun?+
The product should be stored at ambient temperature, preferably below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight, and extreme temperature fluctuations to maintain sterility and solution stability.
How is Natriumhydrogenkarbonat B. Braun administered?+
It is administered intravenously, typically by slow infusion through a calibrated infusion set. The rate and volume are adjusted according to the patient’s blood gas analysis and electrolyte profile, under continuous clinical monitoring.
What are the most serious risks associated with Natriumhydrogenkarbonat B. Braun?+
Serious risks include severe metabolic alkalosis, hypernatremia, pulmonary edema, and cardiac arrhythmias. These complications are more likely with rapid or excessive dosing, especially in patients with compromised renal or cardiac function, and require prompt medical attention.
Who should not receive Natriumhydrogenkarbonat B. Braun?+
Patients with known hypersensitivity to sodium bicarbonate, uncontrolled hypertension, severe heart failure, or those at risk of fluid overload should avoid this product unless a clinician determines that benefits outweigh risks. Individual assessment is essential before administration.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Sodium Hydrogen Carbonate
Route
Intravenous Use
Manufacturer
B.Braun Melsungen Ag
Origin
EU

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