Natriumcitrat Grifols (Sodium Citrate)

Sodium citrate, the active ingredient in Natriumcitrat Grifols, is an anticoagulant presented as a solution for extracorporeal use. It provides anticoagulation during procedures such as hemodialysis, cardiopulmonary bypass and plasma exchange. GNH USA supplies Natriumcitrat Grifols as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Sodium citrate is used to provide anticoagulation during extracorporeal procedures.

Hemodialysis: maintains circuit patency by preventing clot formation. Cardiopulmonary bypass: reduces coagulation within the bypass circuit. Plasma exchange: supports anticoagulation during therapeutic plasma removal.

Sodium citrate may cause a range of adverse reactions, from mild to serious.

Common Side Effects: - Metallic taste - Mild nausea or vomiting - Transient hypotension during infusion - Flushing or warmth sensation - Mild electrolyte shifts (e.g., low calcium) - Local irritation at the infusion site

Serious or Rare Side Effects: - Severe hypocalcemia leading to tetany or seizures - Cardiac arrhythmias or cardiac arrest - Metabolic alkalosis - Profound hypotension requiring intervention - Anaphylactic or severe allergic reactions - Thrombosis due to over‑correction of calcium balance

When using sodium citrate, several safety considerations are recommended. - Renal impairment: monitor serum calcium and adjust infusion rate. - Cardiac disease: observe for hypotension and arrhythmias. - Electrolyte imbalance: assess calcium levels before and during therapy. - Concurrent anticoagulants: consider additive anticoagulant effect. - Pregnancy: limited data, use only if benefit outweighs risk. - Store at ambient temperature: keep in original container, protect from moisture and light.

Sodium citrate can interact with other agents that affect calcium balance or blood pressure.

Major Interactions (Avoid): - Calcium supplements: may reduce anticoagulant effect. - Other calcium‑binding agents (e.g., EDTA): antagonize action. - High‑dose vitamin D: increase calcium load, counteracting citrate.

Moderate Interactions (Monitor Closely): - Loop diuretics: affect calcium excretion. - ACE inhibitors: potential additive hypotension. - Beta‑blockers: may mask symptoms of hypotension.