Natriumbicarbonat Fresenius (Sodium Hydrogen Carbonate)

Sodium hydrogen carbonate, the active ingredient in Natriumbicarbonat Fresenius, is an alkali presented as a sterile solution for injection for intravenous use. It is employed to correct metabolic acidosis, to aid in the treatment of severe hyperkalemia, and to alkalinize urine in selected patients.

GNH USA supplies Natriumbicarbonat Fresenius as a licensed, GDP‑compliant product originating from the European Union, meeting international quality standards, providing reliable deliveries to hospitals, transplant centres, oncology centres and pharmacies and clinical research institutions worldwide.

Natriumbicarbonat Fresenius, an intravenous alkali, is used to manage disorders of acid‑base balance and related electrolyte disturbances. - Metabolic acidosis: restores systemic pH by supplying bicarbonate ions. - Severe hyperkalemia: facilitates intracellular shift of potassium by correcting acidosis. - Urine alkalinization: raises urinary pH to enhance excretion of certain toxins or prevent stone formation.

Intravenous administration of sodium bicarbonate may be associated with several adverse reactions, ranging from mild to serious.

Common Side Effects: - Local irritation at the injection site. - Transient rise in blood pH (alkalemia). - Mild hypernatremia. - Fluid overload in patients with cardiac failure.

Serious or Rare Side Effects: - Metabolic alkalosis. - Severe hypernatremia with neurological signs. - Pulmonary edema.

When using Natriumbicarbonat Fresenius, clinicians should observe specific precautions to ensure patient safety and product integrity. - Assess baseline arterial pH and bicarbonate levels: determine need for correction. - Monitor serum electrolytes, especially potassium and sodium: adjust infusion accordingly. - Infuse slowly: avoid rapid administration that may cause cardiovascular instability. - Use caution in patients with renal impairment or heart failure: risk of fluid and sodium overload. - Avoid use in untreated metabolic alkalosis: may exacerbate condition. - Store at controlled room temperature: keep in original container, protect from light and moisture.

Sodium bicarbonate can interact with several medications, influencing their efficacy or safety.

Major Interactions (Avoid): - Calcium channel blockers: may enhance hypotensive effect. - Certain antibiotics (e.g., tetracyclines, fluoroquinolones): reduced absorption due to increased gastric pH. - Lithium: decreased renal clearance leading to toxicity.

Moderate Interactions (Monitor Closely): - Digoxin: altered serum potassium may increase risk of toxicity. - Anticoagulants (warfarin): changes in plasma protein binding may affect INR. - Insulin: rapid correction of acidosis can potentiate hypoglycemia.