Europe — EMA
Natrii Fluoridum (18f) Synektik (Sodium Fluoride (18f))
GNH USA supplies Natrii Fluoridum (18f) Synektik (Sodium Fluoride), a fluoride drug for prevention of dental caries and treatment of fluoride deficiency.
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What is Sodium Fluoride (18f)?
Sodium fluoride, the active ingredient in Natrii Fluoridum (18f) Synektik, is a fluoride drug presented as an intravenous solution for intravenous use. It is employed to prevent dental caries and to correct fluoride deficiency, primarily in patients at risk of enamel demineralization.
GNH USA supplies Natrii Fluoridum (18f) Synektik as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Sodium Fluoride (18f) used for?
Natrii Fluoridum (18f) Synektik provides systemic fluoride for conditions related to dental health and fluoride deficiency.
- Dental caries: reduces incidence by enhancing enamel remineralization. - Fluoride deficiency: restores systemic fluoride levels to support tooth and bone health. - High‑risk patients: supplies supplemental fluoride to lower decay risk in individuals with elevated caries susceptibility.
What are the side effects of Sodium Fluoride (18f)?
Systemic fluoride can be associated with a range of adverse reactions, varying from mild to severe.
Common Side Effects: - Nausea: mild stomach upset after infusion. - Vomiting: occasional emesis following administration. - Abdominal pain: transient discomfort in the gastrointestinal tract. - Metallic taste: temporary alteration in taste perception. - Headache: mild headache reported by some patients. - Injection site pain: localized discomfort at the infusion site.
Serious or Rare Side Effects: - Anaphylactic reaction: severe allergic response requiring immediate medical attention. - Hyperfluorosis: excessive fluoride accumulation leading to skeletal or dental abnormalities. - Cardiac arrhythmia: irregular heart rhythm observed in rare cases. - Seizures: neurologic events associated with high serum fluoride levels. - Severe hypocalcemia: marked drop in calcium levels potentially causing tetany.
What precautions apply to Sodium Fluoride (18f)?
When using Natrii Fluoridum (18f) Synektik, several precautions should be observed to ensure safety.
- Pregnancy: use only if clearly needed and prescribed by a qualified healthcare professional. - Renal impairment: monitor fluoride serum concentrations and adjust therapy as needed. - Pediatric use: exercise caution in children; dosage must be individualized. - Concurrent fluoride exposure: avoid excessive additional fluoride from dental products or supplements. - Allergy: discontinue immediately if signs of hypersensitivity such as rash or swelling appear. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the container.
What does Sodium Fluoride (18f) interact with?
Fluoride may interact with certain medicines, requiring attention to avoid reduced efficacy or increased toxicity.
Major Interactions (Avoid): - Calcium supplements: can bind fluoride and diminish its systemic availability. - Aluminum‑containing antacids: may form insoluble complexes with fluoride, reducing absorption. - Thyroid hormone therapy: fluoride can interfere with thyroid function; monitor hormone levels. - Renal dialysis: high fluoride load may accumulate; avoid concurrent use.
Moderate Interactions (Monitor Closely): - Aspirin: may increase risk of gastrointestinal irritation when combined with fluoride. - NSAIDs: monitor renal function as both agents can affect kidney handling. - Bisphosphonates: concurrent use may influence bone remodeling; observe for abnormal bone turnover.
