GNH USA

Europe — EMA

Natecal D3 (Colecalciferol, Calcium Carbonate)

GNH USA supplies Natecal D3 (Colecalciferol), a vitamin D supplement for calcium deficiency, osteomalacia and bone health support. Request a quote for supply.

Colecalciferol, Calcium Carbonate

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What is Colecalciferol, Calcium Carbonate?

Colecalciferol, the active ingredient in Natecal D3, is a vitamin D3 supplement presented as an oral dosage form for oral use. It supports calcium metabolism and bone health in individuals with vitamin D or calcium deficiency.

GNH USA supplies Natecal D3 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Colecalciferol, Calcium Carbonate used for?

Natecal D3 provides vitamin D3 and calcium carbonate to address disorders of mineral metabolism and bone integrity.

- Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels. - Calcium deficiency: supplies elemental calcium to maintain normal serum calcium. - Osteomalacia: aids mineralisation of bone matrix in adults. - Osteoporosis prevention: contributes to bone density maintenance when combined with other therapies. - Hypocalcaemia secondary to hypoparathyroidism: helps raise low calcium concentrations.

What are the side effects of Colecalciferol, Calcium Carbonate?

Natecal D3 may cause adverse reactions, most of which are mild and reversible.

Common Side Effects: - Hypercalcaemia: elevated serum calcium causing fatigue or mild nausea. - Nausea or vomiting. - Constipation or abdominal discomfort. - Headache. - Dry mouth. - Metallic taste.

Serious or Rare Side Effects: - Severe hypercalcaemia leading to renal stones or cardiac arrhythmia. - Hypervitaminosis D with symptoms such as polyuria, polydipsia, and confusion. - Allergic reactions: rash, pruritus, or angio‑edema. - Pancreatitis associated with excessive calcium levels. - Hypercalcaemic crisis requiring emergency medical care.

What precautions apply to Colecalciferol, Calcium Carbonate?

Before initiating therapy with Natecal D3, consider the following safety measures.

- Baseline assessment: check serum calcium, phosphate and 25‑hydroxyvitamin D levels. - Renal function: monitor kidney function in patients with chronic kidney disease. - Hypercalcaemia: avoid use in individuals with existing high calcium concentrations. - Sarcoidosis or granulomatous disease: use with caution as vitamin D activation may be increased. - Concomitant calcium supplements: assess total calcium intake to prevent excess. - Store at room temperature: keep in the original container, protect from moisture and light.

What does Colecalciferol, Calcium Carbonate interact with?

Natecal D3 can influence or be influenced by other medicines; interaction severity varies.

Major Interactions (Avoid): - Thiazide diuretics: may exacerbate hypercalcaemia. - High‑dose vitamin A: increases risk of hypervitaminosis D. - Lithium: can alter calcium metabolism.

Moderate Interactions (Monitor Closely): - Orlistat: reduces absorption of fat‑soluble vitamins including vitamin D. - Antacids containing aluminium or magnesium: may decrease calcium carbonate absorption. - Corticosteroids: can diminish calcium absorption and increase bone loss risk.

Frequently asked questions

What is Natecal D3 used for?+
Natecal D3 is a combined oral supplement of colecalciferol (vitamin D3) and calcium carbonate. It is used to correct vitamin D and calcium deficiencies, support bone health, and manage conditions such as osteomalacia, osteoporosis prevention, and hypocalcaemia when prescribed by a healthcare professional.
How does colecalciferol work in the body?+
Colecalciferol is converted first to 25‑hydroxyvitamin D in the liver and then to the active hormone calcitriol in the kidneys. Calcitriol binds to the vitamin D receptor, stimulating intestinal absorption of calcium and phosphate, which are essential for bone mineralisation and overall calcium homeostasis.
What is the usual dose of Natecal D3?+
The appropriate dose of Natecal D3 is determined by the prescribing clinician based on the patient’s serum vitamin D level, calcium status, age, and underlying medical conditions. Dosage may vary from low maintenance doses to higher therapeutic regimens, and patients should follow the prescriber’s instructions exactly.
Is Natecal D3 safe during pregnancy or breastfeeding?+
Vitamin D and calcium are important during pregnancy and lactation, but the safety of Natecal D3 should be evaluated by a healthcare provider. The prescriber will consider the mother’s nutritional status and any potential risk of excess calcium or vitamin D before recommending the product.
How do I order Natecal D3 from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Natecal D3 compare with other vitamin D supplements?+
Natecal D3 combines vitamin D3 with calcium carbonate, offering both the hormonal component for calcium absorption and a direct source of elemental calcium. Single‑ingredient vitamin D products provide only the hormonal effect, so Natecal D3 may be preferred when simultaneous calcium supplementation is clinically indicated.
What are the storage and handling requirements for Natecal D3?+
Store Natecal D3 at room temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability throughout its shelf life.
How is Natecal D3 administered?+
Natecal D3 is taken orally, usually with food to improve calcium carbonate absorption. The tablet should be swallowed whole with a glass of water unless the prescriber provides an alternative administration instruction.
What are the most serious risks associated with Natecal D3?+
The most serious risks include severe hypercalcaemia, which can lead to kidney stones, cardiac arrhythmias, or pancreatitis, and hypervitaminosis D, which may cause neurological symptoms and renal impairment. Patients should be monitored for signs of excess calcium or vitamin D and report any unusual symptoms promptly.
Who should not use Natecal D3?+
Natecal D3 should be avoided in individuals with known hypercalcaemia, severe renal impairment, active sarcoidosis or other granulomatous diseases, and in patients who are already receiving high doses of calcium or vitamin D unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Colecalciferol, Calcium Carbonate
Route
Oral Use
Manufacturer
Chiesi Limited
Origin
EU

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