Nasoxylin (Oxymetazoline Hydrochloride)

Oxymetazoline Hydrochloride, the active ingredient in Nasoxylin, is an alpha‑adrenergic agonist presented as a nasal spray for intranasal use. It relieves nasal congestion caused by the common cold, sinusitis, and allergic rhinitis in adults and children.

GNH USA supplies Nasoxylin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Oxymetazoline Hydrochloride acts on nasal vascular tone to reduce swelling and improve airflow. - Common cold: alleviates nasal congestion and improves breathing. - Sinusitis: decreases mucosal edema to facilitate sinus drainage. - Allergic rhinitis: reduces nasal blockage associated with allergic inflammation.

Adverse reactions may occur with intranasal oxymetazoline use.

Common Side Effects: - Nasal irritation or burning sensation. - Dryness of the nasal mucosa. - Sneezing or mild itching. - Headache. - Transient taste disturbance.

Serious or Rare Side Effects: - Rebound nasal congestion with prolonged use. - Elevated blood pressure or hypertension. - Tachycardia or arrhythmia. - Severe nasal ulceration or epistaxis. - Allergic reaction such as rash or angioedema.

Before using Nasoxylin, consider the following safety measures. - Duration limit: do not exceed 3‑5 consecutive days of use to avoid rebound congestion. - Cardiovascular disease: avoid if you have uncontrolled hypertension or heart disease. - MAO inhibitor therapy: contraindicated due to risk of hypertensive crisis. - Pediatric use: not recommended for children under 6 years without medical advice. - Pregnancy and lactation: consult a healthcare professional before use. - Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Oxymetazoline may interact with other medicines that affect vascular tone or blood pressure.

Major Interactions (Avoid): - Monoamine oxidase inhibitors (MAOIs): risk of severe hypertension. - Other topical nasal decongestants: additive vasoconstriction leading to rebound congestion.

Moderate Interactions (Monitor Closely):\n- Oral sympathomimetic decongestants (e.g., pseudoephedrine): may increase cardiovascular effects. - Antihypertensive agents (beta‑blockers, ACE inhibitors): monitor blood pressure. - Tricyclic antidepressants: potential for additive adrenergic activity.