Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid (glucocorticoid) presented as a nasal spray for endosinusial use. It reduces nasal inflammation associated with allergic rhinitis and nasal polyps, providing symptomatic relief in adults and children.

GNH USA supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global distribution. Our quality‑assured manufacturing follows EU GMP standards, and we maintain appropriate logistics to ensure product integrity throughout the supply chain.

Fluticasone Propionate acts locally in the nasal mucosa to control inflammation in several upper‑respiratory conditions.

- Allergic rhinitis (seasonal): reduces sneezing, itching and nasal congestion. - Allergic rhinitis (perennial): alleviates chronic nasal discharge and obstruction. - Nasal polyps: decreases polyp size and improves airflow, helping to control symptoms.

Fluticasone Propionate may cause local and systemic adverse reactions.

Common Side Effects: - Nasal irritation or burning sensation. - Epistaxis (nosebleeds). - Headache. - Sore throat or cough. - Altered taste or oral dryness.

Serious or Rare Side Effects: - Nasal septal perforation. - Adrenal suppression with prolonged high‑dose use. - Cataracts or glaucoma. - Severe allergic reaction (anaphylaxis).

Before initiating therapy, consider the following safety measures.

- Assess for active nasal infection: avoid use during acute bacterial or fungal sinusitis. - Hypersensitivity: discontinue if patient shows allergy to fluticasone or other corticosteroids. - Use lowest effective dose: limit exposure to reduce systemic absorption. - Monitor long‑term therapy: watch for signs of adrenal insufficiency or intra‑ocular pressure rise. - Avoid abrupt discontinuation after extended high‑dose treatment: taper if needed. - Store at room temperature: keep in original container, protect from moisture and heat.

Fluticasone Propionate can interact with other medicines that affect corticosteroid metabolism or add glucocorticoid effects.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure. - Systemic corticosteroids: additive glucocorticoid effects can raise risk of adrenal suppression.

Moderate Interactions (Monitor Closely): - Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly raise exposure. - Antifungal azoles (except strong inhibitors): potential for increased levels. - Live vaccines: possible reduced vaccine efficacy.