Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a corticosteroid presented as a nasal spray for endosinusial use. It reduces nasal inflammation through local glucocorticoid activity and alleviates symptoms of allergic rhinitis and other nasal inflammatory disorders in both adults and children seasonally worldwide effectively.

GNH USA supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, ensuring product integrity from manufacture to end‑user.

Fluticasone Propionate nasal glucocorticoid acts locally on the nasal mucosa to control inflammatory conditions.

- Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhoea associated with seasonal or perennial allergies. - Nasal polyposis: helps shrink polyps and improves nasal airflow in patients with chronic sinus disease. - Non‑allergic rhinitis: alleviates nasal irritation and discharge caused by irritant or vasomotor triggers.

Fluticasone propionate is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nasal irritation or burning sensation. - Epistaxis (nosebleeds). - Headache. - Sore throat or hoarseness. - Altered taste or smell.

Serious or Rare Side Effects: - Adrenal suppression with prolonged high‑dose use. - Cataract formation or glaucoma. - Severe allergic reaction (anaphylaxis). - Opportunistic fungal infection of the nasal passages. - Nasal septum perforation (very rare).

Before initiating therapy, consider the following precautions.

- Assess for active nasal infection: avoid use until infection resolves. - Hypersensitivity: discontinue if patient shows allergic reaction to fluticasone or formulation components. - Use lowest effective dose: limit exposure to reduce systemic absorption. - Monitor for signs of adrenal suppression, especially with long‑term or high‑dose therapy. - Avoid abrupt discontinuation: taper if therapy has been prolonged. - Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Fluticasone propionate may interact with other medicines that affect corticosteroid metabolism or systemic effects.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression. - Concurrent systemic corticosteroids: additive effect on hypothalamic‑pituitary‑adrenal axis.

Moderate Interactions (Monitor Closely): - Moderate CYP3A4 inhibitors (e.g., erythromycin, ritonavir): may modestly raise fluticasone levels. - Antifungal azoles (e.g., fluconazole): monitor for increased local effects. - Live vaccines: efficacy may be reduced; consider timing of vaccination.