Nasofan (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Nasofan, is a glucocorticoid presented as a nasal spray for endosinusial use. It reduces inflammation in the nasal passages and is indicated for conditions such as allergic rhinitis and nasal polyps in adults and children.

GNH USA supplies Nasofan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Fluticasone Propionate nasal spray acts on inflammatory processes of the upper airway, providing relief in several ENT conditions.

- Allergic rhinitis: alleviates nasal congestion, itching and sneezing caused by seasonal or perennial allergens. - Nasal polyps: reduces polyp size and improves nasal airflow. - Chronic sinusitis: decreases mucosal edema and promotes sinus drainage. - Non‑allergic rhinitis: mitigates nasal irritation and discharge unrelated to allergens.

Fluticasone Propionate nasal spray may cause local and systemic adverse reactions.

Common Side Effects: - Nasal irritation or burning sensation. - Epistaxis (nosebleeds). - Headache. - Throat irritation or dryness. - Altered taste or bitter taste. - Cough.

Serious or Rare Side Effects: - Adrenal suppression with prolonged high‑dose use. - Vision changes such as cataracts or glaucoma. - Severe allergic reaction (anaphylaxis). - Nasal septum perforation. - Opportunistic fungal infection of the nasal cavity. - Systemic immunosuppression leading to increased infection risk.

Before initiating therapy, consider the following safety measures.

- Assess for active nasal infection: avoid use until infection resolves. - Avoid in patients with known hypersensitivity to fluticasone or formulation excipients. - Use the lowest effective dose: limit duration to the prescribed period. - Monitor for signs of adrenal insufficiency, especially with high‑dose or long‑term therapy. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Fluticasone Propionate nasal spray can interact with other medicines that affect corticosteroid metabolism or increase infection risk.

Major Interactions (Avoid): - Concurrent systemic CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) may raise systemic fluticasone exposure. - Use with other intranasal corticosteroids may increase systemic corticosteroid effects.

Moderate Interactions (Monitor Closely): - Immunosuppressants (e.g., azathioprine) may heighten infection susceptibility. - Antihistamines can increase local irritation when used together. - Nasal decongestant sprays may exacerbate mucosal dryness. - Live vaccines: systemic absorption could theoretically reduce vaccine efficacy.