GNH USA

Europe — EMA

Naproxeno + Esomeprazol Sandoz (Esomeprazole, Naproxen)

GNH USA supplies Naproxeno + Esomeprazol Sandoz (naproxen/esomeprazole), a NSAID and proton pump inhibitor for pain, inflammation and gastro‑protection.

Esomeprazole, Naproxen

Request sourcing

1
Pack/s

What is Esomeprazole, Naproxen?

Naproxen and esomeprazole, the active ingredients in Naproxeno + Esomeprazol Sandoz, are an NSAID and a proton pump inhibitor presented as oral tablets for oral use. The combination is intended to treat pain and inflammation while reducing the risk of gastric irritation that can accompany NSAID therapy.

GNH USA supplies Naproxeno + Esomeprazol Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Esomeprazole, Naproxen used for?

Naproxeno + Esomeprazol Sandoz is used for conditions where pain relief from an NSAID is needed together with protection of the gastric mucosa.

Osteoarthritis: reduces joint pain and inflammation associated with degenerative joint disease. Rheumatoid arthritis: alleviates inflammatory joint pain and swelling in autoimmune arthritis. Dyspepsia or gastro‑oesophageal reflux disease (when NSAID therapy is required): provides symptomatic relief while minimizing acid‑related irritation.

What are the side effects of Esomeprazole, Naproxen?

The following adverse reactions have been reported with the combination product.

Common Side Effects: - Dyspepsia or mild stomach upset - Headache - Dizziness - Nausea or mild vomiting - Constipation or diarrhoea

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulcer perforation - Severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome - Significant liver enzyme elevation or hepatitis - Acute renal impairment or failure - Cardiovascular events such as myocardial infarction or stroke

What precautions apply to Esomeprazole, Naproxen?

Before prescribing Naproxeno + Esomeprazol Sandoz, clinicians should consider several safety aspects. - Assess gastrointestinal risk: evaluate history of ulcers or bleeding. - Monitor renal function: check creatinine and electrolytes in at‑risk patients. - Avoid in known hypersensitivity to NSAIDs or PPIs. - Use the lowest effective dose for the shortest duration needed. - Review concomitant anticoagulant or antiplatelet therapy for bleeding risk. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Esomeprazole, Naproxen interact with?

Drug interaction assessment is essential when using this combination therapy.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Other NSAIDs or aspirin: additive gastrointestinal toxicity. - Corticosteroids: heightened ulcer risk. - Selective serotonin reuptake inhibitors (SSRIs): potential for enhanced bleeding.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect. - Diuretics: risk of reduced renal perfusion. - Methotrexate: decreased clearance leading to toxicity.

Frequently asked questions

What is Naproxeno + Esomeprazol Sandoz used for?+
Naproxeno + Esomeprazol Sandoz is a prescription oral tablet that combines naproxen, an NSAID, with esomeprazole, a proton pump inhibitor. It is used to relieve pain and inflammation in musculoskeletal conditions such as osteoarthritis and rheumatoid arthritis, while also providing protection against gastric irritation that can occur with NSAID therapy.
How does naproxen work in this combination?+
Naproxen works by non‑selectively inhibiting the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins that mediate inflammation, pain, and fever. By lowering prostaglandin levels, naproxen diminishes swelling and discomfort in affected joints and tissues.
What is the usual dose of Naproxeno + Esomeprazol Sandoz?+
The specific dose and dosing schedule for Naproxeno + Esomeprazol Sandoz are determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.
Is Naproxeno + Esomeprazol Sandoz safe during pregnancy or breastfeeding?+
Safety of this combination during pregnancy or lactation has not been fully established. Clinicians generally weigh the potential benefits against risks, and alternative therapies may be considered. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss options with their healthcare provider.
How do I order Naproxeno + Esomeprazol Sandoz from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams across international markets. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.
How does this product compare with taking naproxen alone?+
Naproxen alone provides effective analgesic and anti‑inflammatory action but can increase the risk of gastric irritation, ulceration, or bleeding. Adding esomeprazole offers gastric acid suppression, reducing those gastrointestinal risks. The combination therefore aims to maintain pain relief while improving gastrointestinal safety compared with naproxen monotherapy.
What are the storage and handling requirements for Naproxeno + Esomeprazol Sandoz?+
The tablets should be stored at ambient temperature, preferably below 25 °C, in their original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children. No refrigeration is required.
How is Naproxeno + Esomeprazol Sandoz administered?+
The medication is taken orally, usually with a full glass of water. It may be taken with or without food, but taking it with food can help reduce mild stomach discomfort. Patients should swallow the tablet whole and not crush or chew it.
What are the most serious risks associated with this medication?+
Serious risks include gastrointestinal bleeding or ulcer perforation, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, significant liver injury, acute renal impairment, and cardiovascular events like myocardial infarction or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, vomiting blood, rash, or sudden swelling.
Who should not use Naproxeno + Esomeprazol Sandoz?+
Individuals with known hypersensitivity to naproxen, other NSAIDs, esomeprazole, or any component of the tablet should avoid this product. It is also contraindicated in patients with active gastrointestinal bleeding, severe ulcer disease, advanced renal or hepatic impairment, and those taking certain anticoagulants without close monitoring.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Esomeprazole, Naproxen
Route
Oral Use
Manufacturer
Sandoz Farmaceutica Lda.
Origin
EU

Related products

Apranax Plus

Apranax Plus

Esomeprazole, Naproxen

Bausch Health Ireland Limited
EU
Combolly

Combolly

Esomeprazole, Naproxen

Sandoz Pharmaceuticals D.D.
EU
Emoxen

Emoxen

Esomeprazole, Naproxen

Bausch Health Ireland Limited
EU
Emoxen

Emoxen

Esomeprazole, Naproxen

Bausch Health Ireland Limited
EU