Naproxen

Naproxen, the active ingredient in Naproxen, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as a tablet for oral use. It treats pain, inflammation and fever in adult patients.

GNH USA supplies Naproxen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Naproxen is an NSAID that reduces pain and inflammation across several musculoskeletal and systemic conditions. - Pain: provides analgesic relief for mild to moderate acute pain. - Inflammation: decreases inflammatory response in soft‑tissue injuries. - Fever: lowers elevated body temperature associated with infection or inflammation. - Arthritis: alleviates joint pain and swelling in osteoarthritis and rheumatoid arthritis. - Musculoskeletal disorders: improves function and comfort in back strain, tendonitis and similar conditions.

Adverse reactions to naproxen may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Headache: mild to moderate intensity. - Dizziness: occasional light‑headedness. - Skin rash: mild erythema or pruritus. - Elevated blood pressure: modest rise in systolic/diastolic values.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding: may present with melena or hematemesis. - Renal impairment: reduced urine output or increased serum creatinine. - Hepatotoxicity: abnormal liver enzymes or jaundice. - Cardiovascular events: increased risk of myocardial infarction or stroke. - Severe hypersensitivity: anaphylaxis, angioedema or Stevens‑Johnson syndrome.

Before initiating naproxen therapy, consider the following safety measures. - Assess renal function: avoid use in patients with severe renal insufficiency. - Evaluate cardiovascular risk: use cautiously in individuals with history of heart disease. - Monitor gastrointestinal health: avoid in patients with active ulcers or recent GI bleeding. - Review concomitant medications: check for other NSAIDs, anticoagulants or corticosteroids. - Pregnancy and lactation: discuss risks with a healthcare professional before use. - Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Naproxen can affect the activity of several other medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding. - Other NSAIDs or COX‑2 inhibitors: additive renal and GI toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect. - Diuretics: potential for decreased renal perfusion. - Lithium: naproxen may raise serum lithium levels. - Methotrexate: reduced clearance leading to toxicity.