Naltrexon Hydrochloride Accord (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexon Accord, is an opioid antagonist presented as an oral dosage form for oral use. It treats alcohol dependence and opioid dependence in adult patients. GNH USA supplies Naltrexon Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Naltrexone Hydrochloride is used in the management of substance‑use disorders that involve opioid receptors. - Alcohol dependence: helps maintain abstinence and reduces cravings in adults. - Opioid dependence (relapse prevention): blocks opioid effects to support sustained recovery. - Opioid dependence (detoxification support): reduces withdrawal severity when used as part of a supervised detox program.

Naltrexone Hydrochloride may cause a range of adverse reactions.

Common Side Effects: - Nausea - Headache - Dizziness - Fatigue

Serious or Rare Side Effects: - Hepatotoxicity (elevated liver enzymes, potential liver injury) - Severe allergic reactions (rash, angioedema, anaphylaxis) - Suicidal ideation or worsening depression

When prescribing Naltrexone Hydrochloride, consider the following safety measures. - Liver function monitoring: assess baseline and periodic liver enzymes. - Avoid use in patients with acute hepatitis or severe liver impairment. - Do not initiate in individuals currently dependent on opioids who require analgesia. - Use caution in patients with renal insufficiency; adjust as clinically indicated. - Pregnancy and breastfeeding safety: insufficient data, weigh benefits against potential risks. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Naltrexone Hydrochloride can interact with several medication classes.

Major Interactions (Avoid): - Opioid analgesics: antagonizes analgesic effect, may precipitate withdrawal. - Disulfiram: combined hepatotoxic potential. - Alcohol: may increase risk of liver injury.

Moderate Interactions (Monitor Closely): - Benzodiazepines: enhanced central nervous system depression. - Antidepressants: possible increase in depressive symptoms. - Other hepatotoxic drugs (e.g., isoniazid, methotrexate): monitor liver function closely.