Naltrexon Accord (Naltrexone Hydrochloride)

Naltrexone Hydrochloride, the active ingredient in Naltrexon Accord, is a opioid antagonist presented as a tablet for oral use. It treats alcohol dependence and helps prevent relapse in opioid dependence after detoxification.

GNH USA supplies Naltrexon Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Naltrexon Accord is an opioid antagonist indicated for disorders related to alcohol and opioid use. - Alcohol dependence: reduces cravings and supports sustained abstinence. - Opioid dependence (post‑detoxification): blocks opioid receptors to prevent relapse. - Prevention of relapse in opioid dependence: maintains opioid‑free status after withdrawal.

Naltrexon Accord may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Headache: occasional tension‑type pain. - Dizziness: transient light‑headedness. - Fatigue: feeling of reduced energy.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or liver injury. - Severe depression or suicidal thoughts. - Allergic reactions: rash, itching, swelling, or anaphylaxis.

Before prescribing Naltrexon Accord, clinicians should consider several safety aspects. - Liver function assessment: evaluate hepatic enzymes prior to initiation. - Depression monitoring: watch for worsening mood or suicidal ideation. - Avoid in acute hepatitis: contraindicated in active liver disease. - Renal impairment caution: dose adjustment may be needed in severe renal failure. - Concomitant opioid use: discontinue opioid analgesics to avoid precipitated withdrawal. - Store at below 25°C: keep in the original pack, protect from moisture.

Naltrexon Accord can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Opioid agonists (e.g., morphine, methadone, oxycodone): may precipitate acute withdrawal. - Opioid‑containing cough syrups: can trigger severe withdrawal symptoms.

Moderate Interactions (Monitor Closely): - Benzodiazepines: increased sedation risk when combined. - Hepatotoxic drugs (e.g., high‑dose acetaminophen): may exacerbate liver injury. - Certain antidepressants (e.g., SSRIs): monitor for additive central nervous system effects.