Nalgesin (Naproxen Sodium)

Naproxen sodium, the active ingredient in Nalgesin, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It treats mild to moderate pain, inflammatory musculoskeletal conditions such as osteoarthritis and rheumatoid arthritis, dysmenorrhea, and fever.

GNH USA supplies Nalgesin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nalgesin, an NSAID, is used to manage pain and inflammation across several common conditions.

- Mild to moderate pain: provides analgesia for headaches, dental pain, and musculoskeletal aches. - Osteoarthritis: reduces joint inflammation and improves mobility. - Rheumatoid arthritis: helps control chronic inflammatory joint disease. - Dysmenorrhea: alleviates menstrual cramps and associated discomfort. - Fever: lowers elevated body temperature in acute febrile states.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache: mild to moderate intensity. - Dizziness or vertigo. - Skin rash or mild itching. - Elevated blood pressure. - Fluid retention or mild edema.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe hypersensitivity reactions, including anaphylaxis. - Renal impairment or acute kidney injury. - Hepatotoxicity with elevated liver enzymes. - Cardiovascular events such as myocardial infarction or stroke. - Blood dyscrasias like thrombocytopenia or leukopenia.

Before initiating therapy, consider the following safety measures.

- Assess renal function: avoid use in patients with severe renal impairment. - Evaluate gastrointestinal risk: use with caution in those with a history of ulcers or bleeding. - Review cardiovascular history: consider alternatives for patients with established heart disease. - Monitor blood pressure: NSAIDs can raise systemic pressure. - Avoid concomitant anticoagulants without supervision: increased bleeding risk. - Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Naproxen sodium can affect the activity of several other medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): heightened risk of serious bleeding. - Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding. - Other NSAIDs or COX‑2 inhibitors: additive toxicity to kidneys and GI tract.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function. - Diuretics: may diminish diuretic efficacy and affect fluid balance. - Lithium: NSAIDs can raise lithium levels, risking toxicity.