GNH USA

Europe — EMA

Nalador-500 (Sulprostone)

GNH USA supplies Nalador-500 (Sulprostone), a prostaglandin analog for induction of labor, medical abortion and uterine atony.

Sulprostone

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What is Sulprostone?

Sulprostone, the active ingredient in Nalador-500, is a prostaglandin analog presented as an intravenous injection for obstetric use. It is employed to stimulate uterine contractions for induction of labor, medical abortion, and treatment of uterine atony in pregnant patients.\n\nGNH India supplies Nalador-500 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Sulprostone used for?

Sulprostone acts as a uterotonic prostaglandin analog used in obstetric care.\n\nInduction of labor: promotes coordinated uterine contractions to initiate childbirth.\nMedical abortion: facilitates expulsion of uterine contents in early pregnancy termination.\nTreatment of uterine atony: restores tone after delivery to reduce postpartum hemorrhage.

What are the side effects of Sulprostone?

Adverse reactions may occur with sulprostone administration.\n\nCommon Side Effects:\n- Nausea: mild to moderate upset stomach.\n- Vomiting: occasional emesis following injection.\n- Fever: transient rise in body temperature.\n\nSerious or Rare Side Effects:\n- Uterine rupture: tearing of the uterine wall, requiring emergency care.\n- Severe hypotension: marked drop in blood pressure that may cause dizziness or syncope.\n- Anaphylaxis: rapid allergic reaction with airway compromise and shock.

What precautions apply to Sulprostone?

Clinicians should observe specific safety measures when using sulprostone.\n\nMonitor uterine activity: assess contraction pattern and intensity.\nAssess maternal cardiovascular status: watch for hypotension or arrhythmia.\nUse with caution in patients with asthma: prostaglandins may provoke bronchospasm.\nAvoid in known hypersensitivity: discontinue if allergic signs appear.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Sulprostone interact with?

Sulprostone may interact with other agents that affect uterine tone or cardiovascular function.\n\nMajor Interactions (Avoid):\n- NSAIDs: may diminish uterotonic efficacy.\n- Oxytocin: additive uterine stimulation can increase risk of hyperstimulation.\n\nModerate Interactions (Monitor Closely):\n- Beta‑adrenergic antagonists: may enhance uterine contractility.\n- Magnesium sulfate: can potentiate hypotensive effects.\n- Antihistamines: may mask early signs of allergic reaction.

Frequently asked questions

What is Nalador-500 used for?+
Nalador-500 contains sulprostone, a prostaglandin analog used in obstetrics to induce labor, facilitate medical abortion, and treat uterine atony after delivery. It works by stimulating uterine smooth‑muscle contraction to achieve these therapeutic goals.
How does sulprostone work in the body?+
Sulprostone acts as an agonist at prostaglandin E2 (EP) receptors on uterine smooth‑muscle cells. Activation of these receptors raises intracellular calcium, leading to stronger, coordinated uterine contractions and cervical ripening, which are essential for labor induction and controlling postpartum bleeding.
What is the usual dose of Nalador-500?+
The dosing regimen for Nalador-500 is determined by the prescribing clinician based on the specific indication, patient condition, and clinical guidelines. Healthcare professionals calculate the appropriate intravenous dose and infusion rate for each individual case.
Is Nalador-500 safe during pregnancy or breastfeeding?+
Nalador-500 is intended for use in pregnant patients when uterine stimulation is required, such as for labor induction or medical abortion. Its safety in breastfeeding has not been established, so clinicians weigh the benefits against potential risks before prescribing.
How do I order Nalador-500 from GNH USA?+
To request Nalador-500, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Nalador-500 compare with other uterotonics?+
Nalador-500 (sulprostone) is a prostaglandin E2 analog, whereas oxytocin is a peptide hormone. Sulprostone often provides a more rapid and sustained uterine contraction, which can be advantageous in cases of uterine atony or when oxytocin alone is insufficient. Choice depends on clinical scenario and physician preference.
What are the storage and handling requirements for Nalador-500?+
Nalador-500 should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and potency.
How is Nalador-500 administered?+
Nalador-500 is given by intravenous injection or infusion under direct medical supervision. The exact administration technique, rate, and monitoring parameters are defined by the treating clinician according to the indication and patient response.
What are the most serious risks associated with Nalador-500?+
Serious risks include uterine rupture, severe hypotension, and anaphylactic reactions. These events require immediate medical attention and close monitoring during and after administration, especially in patients with pre‑existing cardiovascular or respiratory conditions.
Who should not use Nalador-500?+
Nalador-500 is contraindicated in patients with known hypersensitivity to sulprostone or other prostaglandin analogs, and it should be used with extreme caution in individuals with severe cardiovascular disease, uncontrolled asthma, or active uterine infection.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Sulprostone
Route
Intravenous Use
Manufacturer
Teofarma S.R.L.
Origin
EU

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