Naklofen Duo (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Naklofen Duo, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve mild to moderate pain and inflammation associated with osteoarthritis, rheumatoid arthritis and other musculoskeletal conditions.

GNH USA supplies Naklofen Duo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium is an NSAID that reduces inflammation and pain in several musculoskeletal disorders.

- Mild to moderate pain: provides analgesia to improve daily functioning. - Osteoarthritis: decreases joint pain and stiffness, supporting mobility. - Rheumatoid arthritis: helps control inflammatory joint damage and pain. - Musculoskeletal inflammation: reduces swelling and discomfort in soft‑tissue injuries.

Adverse reactions may occur with any NSAID therapy and should be monitored.

Common Side Effects: - Gastrointestinal discomfort such as dyspepsia or nausea. - Headache or dizziness. - Elevated liver enzymes. - Mild skin rash. - Fluid retention or peripheral edema.

Serious or Rare Side Effects: - Peptic ulcer disease or gastrointestinal bleeding. - Severe hepatic injury. - Renal impairment or failure. - Cardiovascular events such as myocardial infarction. - Severe skin reactions (e.g., Stevens‑Johnson syndrome).

Before prescribing Diclofenac Sodium, clinicians should consider several safety aspects.

- Renal function: assess baseline kidney status and monitor during therapy. - Hepatic health: evaluate liver enzymes, especially in patients with pre‑existing liver disease. - Cardiovascular risk: avoid long‑term use in patients with established heart disease. - Gastrointestinal history: use with caution in those with ulcer disease or bleeding risk. - Concomitant NSAIDs or anticoagulants: avoid combined use to reduce bleeding risk. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Diclofenac Sodium can affect the pharmacokinetics or pharmacodynamics of several medicines.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of serious bleeding. - Selective COX‑2 inhibitors: additive cardiovascular and gastrointestinal toxicity. - High‑dose aspirin: heightened gastrointestinal adverse events.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function, especially in volume‑depleted patients. - Lithium: NSAIDs can raise lithium serum levels, requiring monitoring. - Methotrexate: reduced clearance may increase toxicity.