Naklofen Duo (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Naklofen Duo, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats mild to moderate pain and inflammatory musculoskeletal conditions such as osteoarthritis and rheumatoid arthritis in adults.

GNH USA supplies Naklofen Duo as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac sodium acts on inflammatory pathways to relieve pain and swelling in several musculoskeletal disorders.

- Mild to moderate pain: provides analgesia for acute or chronic pain conditions. - Osteoarthritis: reduces joint pain and inflammation, improving mobility. - Rheumatoid arthritis: alleviates inflammatory symptoms and joint discomfort. - Acute musculoskeletal injury: helps control pain and swelling after sprains or strains. - Post‑operative pain: offers short‑term relief following surgical procedures when prescribed.

Adverse reactions may occur with diclofenac use and are categorized by frequency and severity.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Abdominal pain: discomfort or cramping. - Headache: transient tension‑type pain. - Dizziness: occasional light‑headedness.

Serious or Rare Side Effects: - Gastrointestinal ulcer or bleeding: potentially life‑threatening. - Liver injury: elevated enzymes or hepatitis. - Renal impairment: reduced kidney function or failure. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Cardiovascular events: increased risk of thrombotic episodes. - Blood dyscrasias: agranulocytosis or thrombocytopenia.

Before prescribing diclofenac, clinicians should evaluate patient‑specific risk factors and monitor for complications.

- Assess renal function: monitor creatinine and adjust use in renal impairment. - Evaluate hepatic status: avoid in severe liver disease. - Use lowest effective dose: limit duration to the shortest period necessary. - Avoid in patients with a history of gastrointestinal ulcer or bleeding. - Contraindicated in third‑trimester pregnancy: risk to fetus. - Store at ambient temperature: keep in the original pack, protect from moisture.

Diclofenac may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased risk of bleeding. - Lithium: heightened lithium toxicity. - Methotrexate: amplified methotrexate toxicity. - SSRIs or SNRIs: additive bleeding risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors: possible decline in renal function. - Diuretics: heightened risk of renal impairment. - Cyclosporine: increased nephrotoxicity potential.