Naklofen (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Naklofen, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular use. It provides analgesic and anti‑inflammatory effects for acute pain, postoperative discomfort, and musculoskeletal inflammation in adult patients.

GNH USA supplies Naklofen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent product quality, regulatory adherence, and reliable logistics for global healthcare providers. Our distribution network covers Europe, Asia, Africa and the Americas, with dedicated support for import documentation and cold‑chain management where required.

Diclofenac sodium is used to manage pain and inflammation associated with several acute and chronic musculoskeletal conditions. - Post‑operative pain: Reduces pain intensity and swelling following surgery. - Acute musculoskeletal pain: Relieves pain and improves mobility in injuries such as sprains or strains. - Osteoarthritis flare‑ups: Decreases joint pain and inflammation during acute exacerbations. - Rheumatoid arthritis exacerbations: Controls inflammatory symptoms when disease activity increases.

Like other NSAIDs, diclofenac sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain. - Headache or dizziness. - Injection site reactions: erythema, swelling, or pain. - Elevated liver enzymes: transient increase in hepatic transaminases.

Serious or Rare Side Effects: - Gastrointestinal ulceration or bleeding. - Severe skin reactions such as Stevens‑Johnson syndrome. - Renal impairment including acute kidney injury. - Cardiovascular events: increased risk of myocardial infarction or stroke. - Hepatotoxicity: clinically significant liver injury.

When prescribing Naklofen, clinicians should consider several safety factors. - Renal function: assess before use and monitor during therapy. - Hepatic function: evaluate liver enzymes prior to initiation. - Gastrointestinal risk: avoid in patients with active ulcer disease. - Cardiovascular risk: use cautiously in patients with a history of heart disease. - Concomitant anticoagulants: increase bleeding risk; monitor coagulation parameters. - Store at ambient temperature: keep in original container, protect from light and moisture.

Diclofenac sodium can interact with a variety of medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Corticosteroids: heightened ulcer risk.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: may reduce renal function. - Diuretics: risk of electrolyte imbalance and renal impairment. - Lithium: diclofenac can increase lithium levels.