Naklofen (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Naklofen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular administration. It reduces pain, inflammation and swelling associated with musculoskeletal disorders, postoperative recovery and other acute inflammatory conditions in adult patients.

GNH USA supplies Naklofen as a licensed, GDP‑compliant product, providing reliable international pharmaceutical sourcing for hospitals, pharmacies and clinics worldwide, with full regulatory documentation and cold‑chain logistics where required. The company ensures batch‑to‑batch consistency and adheres to EU quality standards, supporting global healthcare providers in delivering effective analgesic therapy.

Diclofenac Sodium is an NSAID that alleviates pain and inflammation in various musculoskeletal and postoperative conditions.

- Acute pain: provides rapid relief of moderate to severe pain associated with injury or surgery. - Inflammatory arthritis: reduces joint swelling and improves mobility in conditions such as osteoarthritis and rheumatoid arthritis. - Postoperative pain: controls pain and inflammation following surgical procedures. - Musculoskeletal injuries: alleviates pain and inflammation in sprains, strains and soft‑tissue injuries.

Diclofenac Sodium injection may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain. - Injection site reactions: redness, swelling or mild pain at the intramuscular site. - Headache: transient mild to moderate headache.

Serious or Rare Side Effects: - Severe gastrointestinal ulceration or bleeding. - Hepatotoxicity: elevated liver enzymes or hepatitis. - Anaphylaxis: severe allergic reaction with airway compromise.

When using Diclofenac Sodium injectable, clinicians should observe several precautions to minimize risk.

- Assess renal function: avoid use in patients with severe renal impairment. - Monitor hepatic enzymes: use cautiously in those with liver disease. - Evaluate cardiovascular risk: contraindicated in patients with recent myocardial infarction or uncontrolled hypertension. - Use gastrointestinal protection: consider proton pump inhibitor in patients with ulcer history. - Avoid in hypersensitivity: discontinue if signs of allergic reaction appear. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Diclofenac Sodium may interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity. - Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely): - ACE inhibitors or ARBs: possible reduction in renal function. - Diuretics: risk of renal impairment and electrolyte imbalance. - Methotrexate: decreased clearance leading to toxicity.