Nafloxin (Ciprofloxacin Hydrochloride Monohydrate)

Ciprofloxacin, the active ingredient in Nafloxin, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It treats bacterial conjunctivitis, bacterial keratitis and other susceptible ocular infections in patients requiring topical therapy.

GNH USA supplies Nafloxin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nafloxin is a fluoroquinolone antibiotic indicated for bacterial eye infections.

- Bacterial conjunctivitis: reduces bacterial load and resolves infection of the conjunctiva. - Bacterial keratitis: eradicates causative organisms and promotes corneal healing. - Other susceptible ocular infections: provides broad‑spectrum antibacterial activity to treat various bacterial eye conditions.

Adverse reactions may occur with topical ocular use of Nafloxin.

Common Side Effects: - Eye irritation: transient burning or stinging after instillation. - Redness: mild conjunctival hyperemia. - Tearing: increased lacrimation. - Blurred vision: temporary visual disturbance. - Foreign body sensation: feeling of grit in the eye. - Mild eyelid edema.

Serious or Rare Side Effects: - Allergic reaction: angioedema, swelling of eyelids or face. - Severe ocular inflammation: uveitis or keratitis worsening. - Stevens‑Johnson syndrome or toxic epidermal necrolysis involving the eye. - Corneal ulcer progression despite therapy. - Systemic hypersensitivity: rash, fever, or anaphylaxis. - Vision loss: rare but reported with inappropriate use.

Before prescribing Nafloxin, consider the following precautions.

- Assess allergy: confirm no known hypersensitivity to fluoroquinolones or other ophthalmic agents. - Evaluate infection severity: ensure the infection is bacterial and suitable for topical therapy. - Monitor corneal integrity: avoid use on deep corneal ulcers without specialist oversight. - Use with caution in children: safety data are limited; prescriber discretion is required. - Avoid concurrent systemic fluoroquinolones unless clinically justified. - Store at room temperature: keep in the original container, protect from light and moisture.

Nafloxin may interact with other ocular or systemic medications.

Major Interactions (Avoid): - Systemic fluoroquinolones: concurrent use can increase systemic exposure and toxicity. - Topical corticosteroids: may mask infection signs and delay healing. - Topical anesthetic eye drops: can increase corneal toxicity when combined.

Moderate Interactions (Monitor Closely): - Anticholinergic eye drops: may reduce tear production and affect drug distribution. - Herbal eye preparations: potential unknown interactions; monitor patient response. - Non‑steroidal anti‑inflammatory eye drops: may increase ocular irritation.