Naflox (Norfloxacin)

Norfloxacin, the active ingredient in Naflox, is a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. It exhibits broad‑spectrum activity against Gram‑negative and Gram‑positive bacteria and is indicated for the treatment of bacterial conjunctivitis, bacterial keratitis and other susceptible eye infections in patients requiring topical therapy.

GNH USA supplies Naflox as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, ophthalmology clinics and procurement teams worldwide, with adherence to EU quality standards and regulatory requirements.

Naflox (norfloxacin) is used in ophthalmology to treat bacterial infections of the eye. - Bacterial conjunctivitis: reduces bacterial load and accelerates resolution of redness, discharge and irritation. - Bacterial keratitis: eradicates causative organisms, promoting corneal healing and preserving visual acuity. - Other susceptible ocular infections: controls infection caused by susceptible Gram‑negative and Gram‑positive bacteria in the conjunctiva, cornea or eyelid tissues.

Topical ocular administration of norfloxacin may be associated with local and systemic adverse reactions.

Common Side Effects: - Eye irritation: transient burning or stinging sensation after instillation. - Redness: mild conjunctival hyperemia. - Tearing: increased lacrimation. - Blurred vision: temporary visual disturbance.

Serious or Rare Side Effects: - Anaphylaxis: severe systemic allergic reaction requiring immediate medical attention. - Stevens‑Johnson syndrome or toxic epidermal necrolysis: extensive skin and mucous membrane involvement. - Corneal ulceration: worsening of corneal integrity. - Vision loss: rare but potentially irreversible impairment.

When using Naflox, consider the following precautions. - Pregnancy: safety not established; avoid unless benefits outweigh risks. - Breastfeeding: unknown safety; assess risk before use. - Indicated use only: do not use for prophylaxis or non‑susceptible organisms. - Contact lenses: avoid wearing for at least 15 minutes after instillation. - Allergic reactions: discontinue and seek medical advice if severe signs develop. - Store at room temperature: keep in the original container, protect from light and moisture.

Naflox may interact with other ophthalmic or systemic agents.

Major Interactions (Avoid): - Systemic fluoroquinolones: additive risk of tendon rupture. - Anticholinergic eye drops: may reduce ocular absorption of norfloxacin. - Corticosteroid eye drops: increased risk of secondary infection.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory eye drops: may affect corneal healing. - Other ophthalmic antibiotics: potential antagonism or reduced efficacy. - Herbal supplements affecting CYP enzymes: monitor systemic exposure, although topical absorption is minimal.