Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride and fluticasone propionate, the active ingredients in Nadilaz, are an antihistamine and corticosteroid combination presented as a nasal spray for intranasal use. It treats allergic rhinitis and related nasal congestion in adults and children.

GNH USA supplies Nadilaz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nadilaz, a combination antihistamine and corticosteroid nasal spray, is used to manage allergic rhinitis and related nasal inflammation. - Seasonal allergic rhinitis: reduces sneezing, itching and nasal discharge during pollen seasons. - Perennial allergic rhinitis: controls year‑round symptoms caused by indoor allergens. - Nasal congestion due to allergic inflammation: decreases swelling of nasal passages and improves airflow.

Nasal spray therapy may cause local and systemic reactions.

Common Side Effects: - Nasal irritation or burning sensation - Headache - Bitter taste after administration - Epistaxis (nosebleed) - Throat irritation - Cough

Serious or Rare Side Effects: - Nasal septal perforation - Severe allergic reaction (anaphylaxis) - Vision changes or increased intra‑ocular pressure - Adrenal suppression with prolonged use - Fungal sinusitis - Systemic corticosteroid effects such as hyperglycemia

Before using Nadilaz, consider the following safety measures. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: discuss potential risks with a physician. - Nasal surgery or trauma: postpone use until the nasal mucosa has healed. - Use only as directed: avoid excessive dosing to reduce local irritation. - Known hypersensitivity: do not use if allergic to azelastine, fluticasone, or any excipients. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Nadilaz may interact with other medicines; monitor the following.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase fluticasone exposure. - Live vaccines: systemic corticosteroid effect could reduce vaccine efficacy. - MAO inhibitors: may heighten hypertensive responses when combined with azelastine.

Moderate Interactions (Monitor Closely): - Oral antihistamines: additive sedative effect. - Beta‑blockers: may blunt response to epinephrine in anaphylaxis. - Ritonavir or other potent CYP3A4 inhibitors: may raise fluticasone levels.