Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride / fluticasone propionate, the active ingredients in Nadilaz, are an intranasal antihistamine and corticosteroid combination presented as a nasal spray for nasal use. It treats allergic rhinitis, including seasonal forms, in patients requiring prescription therapy.

GNH USA supplies Nadilaz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nadilaz is indicated for allergic rhinitis and works on the nasal inflammatory pathway to relieve symptoms.

Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhea. Seasonal allergic rhinitis: controls symptoms triggered by pollen or seasonal allergens. Perennial allergic rhinitis: provides year‑round relief from allergen‑induced nasal inflammation.

Adverse reactions may occur with intranasal use of Nadilaz.

Common Side Effects: - Nasal irritation or burning sensation. - Headache. - Bitter taste. - Epistaxis (nosebleed). - Throat irritation. - Cough.

Serious or Rare Side Effects: - Nasal septal perforation. - Severe or prolonged epistaxis. - Adrenal suppression with prolonged high‑dose use. - Hypersensitivity reactions including angioedema. - Opportunistic fungal infection of the nasal passages. - Visual disturbances such as blurred vision.

Before using Nadilaz, consider the following safety measures.

Pregnancy: consult a prescriber; limited safety data are available. Breastfeeding: weigh potential benefits against possible risks to the infant. Concomitant nasal surgery: postpone use until the surgical site has healed. Use in children: follow age‑specific labeling and dosing recommendations. Hypersensitivity: avoid if known allergy to azelastine, fluticasone, or any excipients. Store at room temperature: keep in the original container, protect from moisture and light.

Nadilaz may interact with other medicines; monitor patients accordingly.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors: may increase systemic fluticasone exposure. - Live vaccines: systemic corticosteroid effect could reduce vaccine efficacy. - Monoamine oxidase inhibitors: additive antihistamine effects may increase sedation.

Moderate Interactions (Monitor Closely): - Oral antihistamines: may enhance sedation or anticholinergic effects. - Beta‑blockers: could mask signs of severe allergic reactions. - Nasal decongestants: overuse may lead to rebound congestion.