Nacrez (Desogestrel)

Desogestrel, the active ingredient in Nacrez, is a progestogen (progestin) presented as an oral tablet for oral use. It is used for the prevention of pregnancy in women of reproductive age.\n\nGNH India supplies Nacrez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Desogestrel is a progestogen used in hormonal contraception to prevent pregnancy.\n\nContraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus.\nFamily planning: provides reliable, reversible birth control for women.\nMenstrual regulation: may contribute to more predictable menstrual cycles when used as directed.

Desogestrel may cause a range of adverse reactions, most of which are mild and transient.\n\nCommon Side Effects:\n- Nausea\n- Headache\n- Breast tenderness\n- Irregular vaginal bleeding\n- Weight gain\n- Mood changes\n\nSerious or Rare Side Effects:\n- Venous thromboembolism (blood clots)\n- Arterial thrombosis (stroke, myocardial infarction)\n- Severe allergic reaction (anaphylaxis)\n- Liver dysfunction or jaundice\n- Depression or severe mood disorders\n- Hypertension

Before prescribing Desogestrel, clinicians should evaluate individual risk factors and contraindications.\n\nContraindications: known or suspected pregnancy, active thromboembolic disease, severe liver disease, hormone‑dependent tumors.\nSmoking: avoid use in women over 35 who smoke due to increased cardiovascular risk.\nMedical history: assess cardiovascular, hepatic, and metabolic conditions prior to initiation.\nDrug interactions: review concomitant medications that may affect efficacy or safety.\nMonitoring: periodic blood pressure and lipid profile checks are advisable.\nStore at ambient temperature: keep in original container, protect from moisture and heat.

Desogestrel can interact with several medicines, affecting its effectiveness or safety.\n\nMajor Interactions (Avoid):\n- Strong enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin) may markedly reduce contraceptive efficacy.\n- Antifungal azoles (e.g., ketoconazole) can increase plasma levels, raising risk of side effects.\n- Protease inhibitors (e.g., ritonavir) may lower effectiveness of the progestogen.\n\nModerate Interactions (Monitor Closely):\n- Selective serotonin reuptake inhibitors (SSRIs) may exacerbate mood changes.\n- Antihypertensive agents may have altered blood pressure effects due to fluid retention.\n- Herbal supplements such as St. John's wort may decrease contraceptive reliability.