Naclof (Diclofenac Sodium)

Diclofenac Sodium, the active ingredient in Naclof, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an ophthalmic solution for ocular use. It is employed to reduce inflammation and relieve pain in various eye conditions.

GNH USA supplies Naclof as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diclofenac Sodium ophthalmic solution acts on ocular inflammatory pathways to manage eye conditions.

- Post‑operative ocular inflammation: reduces swelling and pain after eye surgery. - Ocular pain: provides analgesic relief for eye discomfort. - Allergic conjunctivitis: helps alleviate inflammation and itching associated with allergic eye reactions.

Adverse ocular reactions may occur with the use of diclofenac sodium eye drops.

Common Side Effects: - Eye irritation or burning sensation - Stinging upon instillation - Blurred vision - Foreign body sensation - Conjunctival hyperemia - Mild headache

Serious or Rare Side Effects: - Corneal ulceration or erosion - Increased intra‑ocular pressure - Severe allergic reaction (e.g., angio‑edema) - Stevens‑Johnson syndrome affecting the eye - Vision loss or significant visual impairment - Persistent or worsening ocular inflammation

Before prescribing diclofenac sodium ophthalmic solution, clinicians should consider several safety aspects.

- Assess for ocular infection: avoid use if active infection is present. - Hypersensitivity: do not use in patients with known allergy to diclofenac or other NSAIDs. - Corneal disease: use with caution in patients with corneal ulcers or keratitis. - Glaucoma: monitor intra‑ocular pressure in patients with glaucoma. - Concurrent NSAID eye drops: avoid simultaneous use to prevent additive toxicity. - Store at room temperature: keep in the original container, protect from light and moisture.

Diclofenac sodium eye drops can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid): - Concurrent ophthalmic NSAIDs: increased risk of ocular toxicity. - Systemic NSAIDs: potential additive systemic exposure and gastrointestinal risk. - Anticoagulants (e.g., warfarin): heightened bleeding tendency in ocular tissues.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may mask signs of infection. - Beta‑blocker eye drops: possible alteration of intra‑ocular pressure control. - Contact lens wear: may increase drug absorption and irritation.