GNH USA

Europe — EMA

Nabilone

GNH USA supplies Nabilone (Nabilone), a synthetic cannabinoid for chemotherapy‑induced nausea, postoperative nausea and AIDS‑related anorexia.

Nabilone

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What is Nabilone?

Nabilone, the active ingredient in Nabilone, is a synthetic cannabinoid presented as an oral tablet for oral use. It is employed to alleviate chemotherapy‑induced nausea and vomiting, postoperative nausea and vomiting, and to stimulate appetite in patients with AIDS‑related weight loss.

GNH USA supplies Nabilone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑compliant documentation for global distribution. Customers benefit from reliable lead times and dedicated technical support throughout the procurement process.

What is Nabilone used for?

Nabilone is a synthetic cannabinoid used to manage nausea and vomiting across several clinical settings.

Chemotherapy-induced nausea and vomiting: reduces frequency and severity of nausea and vomiting in patients receiving cytotoxic therapy. Postoperative nausea and vomiting: helps prevent and treat nausea and vomiting after surgical procedures. AIDS-related anorexia and weight loss: stimulates appetite and promotes weight gain in patients with HIV/AIDS.

What are the side effects of Nabilone?

Nabilone may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Drowsiness: feeling unusually sleepy or fatigued. - Dry mouth: reduced salivation leading to throat discomfort. - Dizziness: sensation of lightheadedness or imbalance. - Euphoria or mood changes: mild alterations in mood or perception. - Nausea: paradoxical feeling of nausea. - Vomiting: occasional episodes despite antiemetic action.

Serious or Rare Side Effects: - Psychosis: hallucinations, delusions, or severe confusion. - Severe hypotension: marked drop in blood pressure causing faintness. - Allergic reactions: rash, itching, swelling, or anaphylaxis. - Seizures: rare occurrence of convulsive episodes.

What precautions apply to Nabilone?

When prescribing Nabilone, clinicians should consider several precautionary measures to ensure safe use.

Assess hepatic function: adjust use in patients with severe liver impairment. Monitor for psychiatric symptoms: watch for anxiety, depression, or psychotic changes. Avoid concurrent CNS depressants: increased sedation risk with alcohol or opioids. Pregnancy and lactation: use only if potential benefit justifies potential risk. Driving and machinery: caution due to possible dizziness or drowsiness. Store at ambient temperature: keep below 25°C in original container, protect from moisture.

What does Nabilone interact with?

Nabilone can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid): - CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase Nabilone plasma levels, raising risk of toxicity. - Centrally acting depressants (e.g., benzodiazepines, opioids): can enhance sedation and respiratory depression.

Moderate Interactions (Monitor Closely): - CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce Nabilone effectiveness. - Anticholinergic agents: may exacerbate dry mouth. - Antihypertensives: possible additive hypotensive effect.

Frequently asked questions

What is Nabilone used for?+
Nabilone is prescribed to treat nausea and vomiting that result from chemotherapy, surgery, or AIDS‑related weight loss. It helps patients who have not responded adequately to conventional antiemetics by targeting the cannabinoid pathways that control the emetic response.
How does Nabilone work?+
Nabilone works as a partial agonist at cannabinoid CB1 receptors in the brain. Activation of these receptors modulates neurotransmitter release involved in the vomiting reflex, thereby reducing the sensation of nausea and the physical act of vomiting.
What is the usual dose of Nabilone?+
The dosage of Nabilone is individualized. A qualified prescriber determines the appropriate strength, frequency, and duration based on the patient’s clinical condition, response, and tolerance. No fixed regimen should be assumed without professional guidance.
Is Nabilone safe during pregnancy or breastfeeding?+
Safety data for Nabilone in pregnancy and lactation are limited. It should be used only if the potential benefit outweighs the possible risk to the fetus or infant, and the decision must be made by the treating physician.
How do I order Nabilone from GNH USA?+
To request Nabilone, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nabilone compare with other antiemetic options?+
Compared with standard antiemetics such as ondansetron, Nabilone targets the cannabinoid system rather than serotonin receptors, offering an alternative mechanism of action. It is often considered when patients have inadequate control with first‑line agents. Dronabinol is another synthetic cannabinoid with a similar profile, but Nabilone may have a slightly different side‑effect spectrum.
How should Nabilone be stored and handled?+
Nabilone tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiration date.
How is Nabilone administered?+
Nabilone is taken orally, usually with a glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable blood levels. Patients should follow the prescriber’s instructions regarding timing and dosing.
What are the most serious risks associated with Nabilone?+
Serious adverse events include psychosis or severe mood disturbances, marked hypotension that can cause fainting, and rare seizures. Patients should be monitored for any sudden changes in mental status, blood pressure, or neurological symptoms, and medical attention sought promptly if these occur.
Who should not use Nabilone?+
Nabilone is contraindicated in individuals with known hypersensitivity to the drug, severe hepatic impairment, active psychotic disorders, or in patients where the risk outweighs benefit, such as certain pregnant or breastfeeding women. A healthcare professional should evaluate each case before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Nabilone
Route
Oral Use
Manufacturer
Mylan Products Limited
Origin
EU

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