GNH USA

Europe — EMA

Mysimba (Bupropion Hydrochloride, Naltrexone Hydrochloride)

GNH USA supplies Mysimba (Bupropion Hydrochloride/Naltrexone Hydrochloride), an appetite suppressant for obesity and weight management. Request a quote.

Bupropion Hydrochloride, Naltrexone Hydrochloride

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What is Bupropion Hydrochloride, Naltrexone Hydrochloride?

bupropion hydrochloride/naltrexone hydrochloride, the active ingredient in Mysimba, is a centrally acting appetite suppressant (combination) presented as a tablet/oral for oral use. It treats obesity and assists weight management in overweight adults with related health conditions.

GNH USA supplies Mysimba as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Bupropion Hydrochloride, Naltrexone Hydrochloride used for?

Mysimba is indicated for obesity and related weight‑management pathways. - Obesity: helps reduce body weight in adults with a body‑mass index (BMI) ≥30 kg/m². - Overweight with comorbidities: supports weight loss in adults with BMI ≥27 kg/m² plus hypertension, type 2 diabetes or dyslipidaemia. - Weight‑management adjunct: used alongside diet, exercise and behavioural therapy to improve long‑term weight outcomes.

What are the side effects of Bupropion Hydrochloride, Naltrexone Hydrochloride?

Mysimba may cause a range of adverse reactions.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Constipation: reduced bowel movements. - Headache: intermittent pain. - Dry mouth: reduced salivation. - Insomnia: difficulty falling or staying asleep. - Dizziness: light‑headed sensation.

Serious or Rare Side Effects: - Hypertension: elevated blood pressure requiring monitoring. - Seizures: risk increased especially at high doses. - Suicidal thoughts: emergence of depressive or suicidal ideation. - Severe allergic reaction: rash, swelling, or anaphylaxis. - Liver injury: abnormal liver enzymes or hepatitis. - Mood changes: agitation or anxiety.

What precautions apply to Bupropion Hydrochloride, Naltrexone Hydrochloride?

Before prescribing Mysimba, clinicians should consider several safety factors. - Cardiovascular assessment: monitor blood pressure and heart rate regularly. - Seizure history: avoid use in patients with a prior seizure disorder. - Psychiatric evaluation: assess risk of suicidal thoughts or mood disorders. - Pregnancy and lactation: prescribe only if potential benefit outweighs risk. - Concomitant medications: review for interactions with MAO inhibitors or other bupropion‑containing products. - Store at ambient temperature: keep below 25°C, protect from moisture and light.

What does Bupropion Hydrochloride, Naltrexone Hydrochloride interact with?

Mysimba can interact with several drug classes, requiring careful management.

Major Interactions (Avoid): - MAO inhibitors: concurrent use may cause hypertensive crisis. - Other bupropion‑containing products: increased risk of seizures. - Opioid agonists: naltrexone may block analgesic effect.

Moderate Interactions (Monitor Closely): - CYP2B6 inhibitors (e.g., clopidogrel): may raise bupropion levels. - CYP3A4 inhibitors (e.g., ketoconazole): may increase naltrexone exposure. - Serotonergic agents (e.g., SSRIs): potential for serotonin syndrome.

Frequently asked questions

What is Mysimba used for?+
Mysimba is a prescription medication used to treat obesity and to support weight management in overweight adults who have additional health conditions such as hypertension, type 2 diabetes or dyslipidaemia. It is intended to be used together with a reduced‑calorie diet and increased physical activity.
How does bupropion hydrochloride/naltrexone hydrochloride work?+
The combination works by influencing two pathways in the brain. Bupropion increases the activity of norepinephrine and dopamine, stimulating appetite‑suppressing neurons in the hypothalamus. Naltrexone blocks opioid receptors that normally limit this signal, thereby enhancing the overall reduction in food intake and the reward response to eating.
What is the usual dose of Mysimba?+
The specific dose and titration schedule for Mysimba are determined by the prescribing clinician based on the individual’s medical history, body‑mass index and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.
Is Mysimba safe during pregnancy or breastfeeding?+
Safety data for Mysimba in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Mysimba from GNH USA?+
To request Mysimba, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Mysimba compare with other obesity drugs?+
Mysimba is unique because it combines a norepinephrine‑dopamine reuptake inhibitor with an opioid antagonist, targeting both appetite and reward pathways. Other approved obesity agents may act solely on gastric motility, fat absorption or single neurotransmitter systems, which can result in different efficacy and side‑effect profiles.
What are the storage and handling requirements for Mysimba?+
Mysimba tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use after the expiry date printed on the packaging.
How is Mysimba administered?+
Mysimba is taken orally as a tablet. The usual practice is to start with a low dose and gradually increase, as directed by the prescriber, to minimise side effects. Tablets should be swallowed whole with water and taken with or without food according to the clinician’s guidance.
What are the most serious risks associated with Mysimba?+
The most serious risks include elevated blood pressure, seizures, emergence of suicidal thoughts or behaviours, severe allergic reactions, and potential liver injury. Patients should be monitored regularly for these events, and any concerning symptoms should be reported to a healthcare professional immediately.
Who should not use Mysimba?+
Mysimba is contraindicated in individuals with a known hypersensitivity to bupropion, naltrexone or any tablet components, those currently taking monoamine oxidase inhibitors, patients with a seizure disorder, uncontrolled hypertension, or those who are pregnant or breastfeeding unless the prescriber determines that benefits outweigh risks.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Bupropion Hydrochloride, Naltrexone Hydrochloride
Route
Oral Use
Manufacturer
Orexigen Therapeutics Ireland Limited
Origin
EU

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