Myocholine (Bethanechol Chloride)

Bethanechol, the active ingredient in Myocholine, is a cholinergic agonist presented as an oral formulation for oral use. It stimulates smooth muscle contraction in the urinary and gastrointestinal tracts and is employed to manage urinary retention and postoperative ileus in adult patients. It is indicated for use in postoperative settings and for patients with bladder dysfunction.

GNH USA supplies Myocholine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with established distribution networks and regulatory expertise across European and global markets.

Myocholine (bethanechol) acts on muscarinic receptors to promote smooth‑muscle activity in the urinary and gastrointestinal systems.

Urinary retention: improves bladder emptying and facilitates spontaneous voiding. Postoperative ileus: restores intestinal motility after abdominal surgery.

Common Side Effects: - Abdominal cramping or discomfort. - Diarrhea or loose stools. - Increased salivation or drooling. - Sweating and flushing. - Nausea or mild vomiting. - Urinary urgency or frequency.

Serious or Rare Side Effects: - Bronchospasm or severe airway constriction. - Marked hypotension or cardiovascular collapse. - Cardiac arrhythmias, including bradycardia. - Cholinergic crisis with muscle weakness and respiratory depression. - Severe urinary incontinence due to overstimulation.

Before initiating therapy, consider the following precautions: - Assess renal and hepatic function: dose adjustment may be required in impairment. - Monitor for signs of cholinergic excess such as excessive sweating, bradycardia, or gastrointestinal hyperactivity. - Avoid in patients with mechanical obstruction of the urinary tract (e.g., bladder stones, strictures). - Use caution in individuals with asthma, COPD, or other obstructive airway diseases. - Contraindicated in patients with known hypersensitivity to bethanechol or related compounds. - Store at room temperature: keep in the original container, protect from moisture and light.

Myocholine may interact with other medicines as follows:

Major Interactions (Avoid): - Anticholinergic agents (e.g., atropine, scopolamine): may block therapeutic effect. - Cholinesterase inhibitors (e.g., neostigmine, pyridostigmine): can cause excessive cholinergic stimulation. - Non‑selective beta‑blockers: may mask tachycardia associated with cholinergic activity.

Moderate Interactions (Monitor Closely): - Diuretics: electrolyte shifts may influence smooth‑muscle response. - Anesthetic agents such as succinylcholine: additive muscarinic effects. - Certain macrolide antibiotics (e.g., erythromycin): may alter gastrointestinal motility and affect drug absorption.