Myocard (Doxazosin Mesilate)

Doxazosin mesilate, the active ingredient in Myocard, is an alpha-1 adrenergic blocker presented as an oral tablet for oral use. It is indicated for the management of hypertension and for relief of urinary symptoms associated with benign prostatic hyperplasia in adult patients.

GNH USA supplies Myocard as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU marketing authorisation standards and is manufactured under GMP conditions. It is distributed through GNH USA's global logistics network to ensure timely delivery.

Doxazosin mesilate acts on the alpha‑1 adrenergic pathway to control blood pressure and urinary flow.

- Hypertension: lowers systemic blood pressure in patients with elevated readings. - Essential hypertension: provides long‑term control of primary high blood pressure. - Benign prostatic hyperplasia: improves urinary flow and reduces bladder outlet obstruction in men with enlarged prostate.

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Dizziness: feeling light‑headed, especially after standing. - Headache: mild to moderate pain in the head region. - Fatigue: general tiredness or lack of energy. - Nasal congestion: blocked or runny nose. - Peripheral edema: swelling of the ankles or feet. - Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure that can cause fainting. - Syncope: sudden loss of consciousness. - Priapism: prolonged, painful erection. - Angioedema: swelling of face, lips, tongue or throat. - Allergic reaction: rash, itching, or hives. - Liver injury: abnormal liver function tests.

Before initiating therapy, consider the following safety measures.

- Blood pressure monitoring: check baseline and periodic readings. - Hepatic impairment: use with caution in patients with liver disease. - Orthostatic hypotension: advise patients to rise slowly from sitting or lying positions. - Concomitant antihypertensives: adjust doses to avoid excessive blood pressure lowering. - Renal function: assess kidney status, especially in the elderly. - Store at room temperature: keep in the original pack, protect from moisture.

Doxazosin may interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid): - Other alpha‑1 blockers: additive blood pressure reduction. - Potent CYP3A4 inhibitors (e.g., ketoconazole): increased plasma concentrations. - Phosphodiesterase‑5 inhibitors: risk of severe hypotension.

Moderate Interactions (Monitor Closely): - Diuretics: may enhance orthostatic effects. - Beta‑blockers: combined effect on heart rate and blood pressure. - Other antihypertensives: cumulative lowering of blood pressure. - NSAIDs: may blunt antihypertensive response. - Lithium: possible increase in lithium levels.