Mydrane

Lidocaine Hydrochloride, Phenylephrine Hydrochloride and Tropicamide, the active ingredients in Mydrane, are a combination ophthalmic anesthetic and mydriatic presented as an intracameral solution for intracameral use. It provides pupil dilation and intraocular anesthesia for cataract and other intraocular surgeries.

GNH USA supplies Mydrane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Mydrane is used in ophthalmic procedures that require rapid pupil dilation and intraocular anesthesia. - Cataract surgery: achieves effective pupil dilation and local anesthesia to facilitate lens removal. - Trabeculectomy: provides mydriasis and analgesia for glaucoma filtration surgery. - Vitrectomy and other intraocular surgeries: ensures adequate pupil size and comfort during posterior segment procedures.

Mydrane may cause ocular and systemic reactions after intracameral administration.

Common Side Effects: - Transient ocular discomfort or burning sensation. - Mild increase in intraocular pressure. - Temporary blurred vision. - Conjunctival hyperemia. - Mild corneal edema. - Mild headache.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis, angio‑edema). - Sustained elevation of intraocular pressure requiring intervention. - Persistent mydriasis lasting >24 hours. - Corneal endothelial toxicity. - Endophthalmitis or intraocular infection.

Before using Mydrane, consider the following safety measures. - Allergy assessment: verify no hypersensitivity to lidocaine, phenylephrine or tropicamide. - Intraocular pressure monitoring: check baseline IOP and observe post‑administration. - Cardiovascular caution: phenylephrine may raise systemic blood pressure; use cautiously in hypertensive patients. - Glaucoma caution: avoid in patients with narrow‑angle or uncontrolled glaucoma. - Sterile technique: ensure aseptic preparation and administration to prevent infection. - Store at room temperature: keep in original container, protect from light and moisture.

Mydrane may interact with systemic and ocular medications.

Major Interactions (Avoid): - Monoamine oxidase inhibitors: concurrent use with phenylephrine can precipitate hypertensive crisis. - Other topical mydriatics: additive pupil dilation may lead to prolonged mydriasis. - Systemic alpha‑adrenergic agonists: may cause excessive vasoconstriction and hypertension.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: may diminish phenylephrine‑induced pupil dilation. - Cholinergic drugs (e.g., pilocarpine): can antagonize tropicamide effects, reducing mydriasis. - Additional local anesthetics: may increase risk of lidocaine toxicity when used together.