Mycozal (Fluconazole)

Fluconazole, the active ingredient in Mycozal, is an azole antifungal presented as an oral dosage form for oral use. It treats a range of fungal infections including candidiasis, cryptococcal meningitis and systemic mycoses in both adults and children as prescribed.

GNH USA supplies Mycozal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Fluconazole is an azole antifungal used to treat infections caused by susceptible fungi.

- Candidiasis: effective for oropharyngeal, esophageal and vaginal infections. - Cryptococcal meningitis: used for induction and maintenance therapy. - Systemic mycoses: treats disseminated infections such as blastomycosis and histoplasmosis. - Dermatophyte infections: manages skin and nail infections caused by dermatophytes.

Fluconazole may cause a variety of adverse reactions, ranging from mild to severe.

Common Side Effects: - Nausea - Headache - Abdominal pain - Diarrhea - Rash - Elevated liver enzymes

Serious or Rare Side Effects: - Severe hepatic injury - Stevens‑Johnson syndrome - Toxic epidermal necrolysis - Anaphylaxis - QT interval prolongation - Other severe skin reactions

Before initiating fluconazole therapy, clinicians should consider several safety measures.

- Assess liver function: obtain baseline liver‑function tests. - Monitor renal function: adjust dose in severe renal impairment. - Review concomitant medications: avoid drugs that prolong QT or strongly inhibit CYP2C9/2C19. - Use caution in pregnancy: weigh potential risks against benefits. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Store at ambient temperature: keep in the original container, protect from moisture and light.

Fluconazole interacts with several medicines; some combinations should be avoided while others require monitoring.

Major Interactions (Avoid): - Cisapride: risk of serious arrhythmia. - Terfenadine: may cause QT prolongation. - Potent CYP2C9 inhibitors (e.g., warfarin): increased anticoagulant effect. - Rifampin: reduces fluconazole plasma levels. - Azithromycin: heightened QT‑interval risk.

Moderate Interactions (Monitor Closely): - Oral contraceptives: possible reduction in efficacy. - Phenytoin: may lower fluconazole concentrations. - Carbamazepine: can decrease fluconazole exposure. - Statins (e.g., simvastatin): increased myopathy risk. - HIV protease inhibitors: may raise fluconazole levels.