Mycostatin (Nystatin)

Nystatin, the active ingredient in Mycostatin, is a polyene antifungal presented as an oral formulation for oral use. It treats oral and gastrointestinal candidiasis in patients who require antifungal therapy.

GNH USA supplies Mycostatin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mycostatin is a polyene antifungal used to manage fungal infections of the oral cavity and gastrointestinal tract. - Oral candidiasis (thrush): reduces fungal load and resolves symptoms such as white plaques and discomfort. - Gastrointestinal candidiasis: eradicates Candida overgrowth in the digestive system, relieving abdominal pain and diarrhea. - Prophylaxis in patients on broad‑spectrum antibiotics: helps prevent secondary Candida infection by maintaining fungal balance.

Nystatin is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Vomiting: occasional episodes after ingestion. - Diarrhea: loose stools during treatment. - Abdominal cramps: discomfort in the lower abdomen. - Altered taste: temporary metallic or bitter sensation. - Mild skin rash: localized erythema at the mouth.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction with difficulty breathing. - Stevens‑Johnson syndrome: rare severe skin eruption. - Hepatic dysfunction: signs of liver injury such as jaundice. - Severe gastrointestinal upset: persistent vomiting or bloody stools. - Nephrotoxicity: rare kidney impairment when used with other nephrotoxic agents. - Hematologic abnormalities: uncommon drops in white blood cell counts.

Before prescribing Mycostatin, consider the following safety measures. - Assess renal function: adjust use in patients with severe renal impairment. - Monitor for hypersensitivity: discontinue if signs of allergic reaction appear. - Use cautiously in premature infants: limited safety data are available. - Avoid in patients with known hypersensitivity to polyene antifungals. - Review concomitant antibiotic therapy: broad‑spectrum antibiotics may alter efficacy. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Nystatin may interact with other medicines; awareness of the interaction level is important.

Major Interactions (Avoid): - Concurrent systemic amphotericin B: increased risk of nephrotoxicity. - High‑dose oral corticosteroids: may diminish antifungal effectiveness.

Moderate Interactions (Monitor Closely): - Broad‑spectrum antibiotics: may disrupt gut flora and affect Candida colonisation. - Antacids containing aluminum or magnesium: could affect dissolution of oral suspension. - Oral probiotics: may compete with Nystatin activity, requiring monitoring of therapeutic response.