Mycostatin (Nystatin)

Nystatin, the active ingredient in Mycostatin, is a polyene antifungal presented as an oral formulation for oral use. It treats oral, esophageal and gastrointestinal candidiasis in patients with confirmed fungal infection.

GNH USA supplies Mycostatin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Mycostatin is a polyene antifungal indicated for Candida infections of the oral and gastrointestinal tracts. - Oral candidiasis (thrush): reduces fungal load and resolves oral lesions. - Esophageal candidiasis: treats infection and alleviates dysphagia. - Gastrointestinal candidiasis: eradicates Candida overgrowth in the GI tract.

Adverse reactions may occur with Mycostatin use.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Vomiting: occasional episodes after dosing. - Abdominal discomfort: cramping or pain. - Diarrhea: loose stools. - Altered taste: metallic or unpleasant flavor. - Mild skin rash: localized erythema.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Hepatic dysfunction: signs of liver injury such as jaundice. - Severe neutropenia: marked reduction in white blood cells. - Stevens‑Johnson syndrome: severe skin and mucous membrane reaction. - Severe mucosal ulceration: extensive ulcer formation in the mouth or esophagus. - Systemic fungal infection: rare dissemination of Candida.

Before prescribing Mycostatin, clinicians should consider several safety measures. - Assess renal function: adjust use in severe impairment. - Monitor for allergic reactions: discontinue if severe hypersensitivity occurs. - Evaluate hepatic status: use cautiously in liver disease. - Confirm Candida infection: avoid unnecessary exposure. - Avoid concomitant nephrotoxic drugs: increase renal monitoring. - Store at ambient temperature: keep in original container, protect from moisture and light.

Mycostatin may interact with other medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid): - Concomitant nephrotoxic antibiotics (e.g., amphotericin B): increased renal toxicity. - Co‑administration with live oral vaccines: risk of disseminated infection. - Use with systemic azole antifungals: antagonistic effect reducing nystatin efficacy.

Moderate Interactions (Monitor Closely): - Antacids containing aluminum or magnesium: may decrease oral absorption. - Broad‑spectrum antibiotics: can alter gut flora and affect Candida balance. - Oral contraceptives: possible reduction in hormonal effectiveness.