Mustef (Dimethyl Fumarate)

Dimethyl fumarate, the active ingredient in Mustef, is a fumaric acid ester presented as an oral dosage form for oral use. It is used to treat relapsing forms of multiple sclerosis and moderate to severe plaque psoriasis in adult patients. GNH USA supplies Mustef as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Dimethyl fumarate is employed as a disease‑modifying therapy for immune‑mediated disorders.

- Multiple sclerosis: reduces relapse frequency and slows disability progression. - Psoriasis: improves skin lesions and decreases disease severity.

Adverse reactions to dimethyl fumarate may vary in frequency and severity.

Common Side Effects: - Flushing: transient redness and warmth, often on the face. - Gastrointestinal upset: nausea, abdominal pain, or diarrhea. - Lymphopenia: reduced lymphocyte count, usually mild. - Headache: mild to moderate intensity. - Pruritus: itching of the skin.

Serious or Rare Side Effects: - Progressive multifocal leukoencephalopathy (PML): rare opportunistic brain infection. - Severe lymphopenia: may predispose to serious infections. - Hepatic injury: elevated liver enzymes or hepatitis. - Anaphylaxis: rare severe allergic reaction.

When prescribing or dispensing Mustef, several safety considerations are recommended.

- Monitor lymphocyte count: baseline and periodic testing to detect lymphopenia. - Assess liver function: regular monitoring of transaminases is advised. - Avoid in active infection: increased risk of opportunistic infections. - Pregnancy: safety not established; use only if benefit outweighs risk. - Store at ambient temperature: keep below 25°C, protect from moisture, retain original packaging.

Dimethyl fumarate may interact with other medicines, requiring attention to potential risks.

Major Interactions (Avoid): - Immunosuppressants: may increase infection risk. - Live vaccines: contraindicated due to immunomodulation. - Other Nrf2 activators: potential additive antioxidant effects.

Moderate Interactions (Monitor Closely): - Anticonvulsants: may alter plasma concentrations. - Statins: possible increased risk of myopathy. - Antihypertensives: monitor blood pressure for additive effects.