Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a prostaglandin analog presented as a 125 µg urethral suppository for urethral use. It facilitates erection by increasing blood flow to the penis and is indicated for the treatment of erectile dysfunction in adult males. It is administered directly into the urethra shortly before sexual activity, allowing rapid onset of effect.

GNH USA supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide, ensuring quality, traceability and compliance with EU standards.

Alprostadil is a prostaglandin analog used to manage erectile dysfunction by enhancing penile blood flow. - Erectile dysfunction (general): improves the ability to achieve and maintain an erection sufficient for sexual activity. - Erectile dysfunction secondary to diabetes: helps overcome vascular limitations associated with diabetic patients. - Erectile dysfunction after prostate surgery: supports penile erection in men recovering from nerve‑sparing prostatectomy.

Alprostadil may cause a range of adverse reactions. Patients should be informed of both frequent and less common events.

Common Side Effects: - Penile pain or discomfort during or after insertion. - Urethral burning or stinging sensation. - Light vaginal bleeding in female partners. - Headache. - Dizziness or light‑headedness. - Nausea.

Serious or Rare Side Effects: - Priapism lasting longer than four hours. - Severe hypotension or syncope. - Allergic reaction including rash, itching, or swelling. - Urethral trauma or infection. - Hematoma at the insertion site.

Before using Muse, consider the following safety measures. - Cardiovascular assessment: ensure the patient can tolerate sexual activity without undue risk. - Contraindicate use with nitrate therapy: combined effect may cause dangerous hypotension. - Evaluate bleeding risk: patients with coagulopathies may experience increased urethral bleeding. - Provide insertion instructions: correct technique reduces trauma and discomfort. - Store at room temperature: keep in the original packaging, protect from moisture and heat.

Alprostadil can interact with other medications; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid): - Nitrates (e.g., nitroglycerin): additive vasodilatory effect may cause severe hypotension. - Alpha‑blockers (e.g., tamsulosin): risk of marked blood pressure drop.

Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): may increase risk of urethral bleeding. - Antihypertensive agents: monitor blood pressure for additive lowering. - Other prostaglandin preparations: potential for excessive vasodilation.