Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a prostaglandin E1 analog presented as a 125 µg urethral suppository for urethral administration. It is indicated for the treatment of erectile dysfunction in adult males by facilitating penile erection when sexual stimulation occurs.

GNH USA supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality‑controlled sourcing and regulatory compliance for global distribution. The company adheres to EU Good Manufacturing Practice standards and provides comprehensive documentation for import and customs clearance.

Alprostadil is a prostaglandin E1 analog used to manage erectile dysfunction, a condition involving impaired penile blood flow.

- Erectile dysfunction: improves ability to achieve and maintain penile erection during sexual activity. - Penile vascular insufficiency: enhances blood flow to the corpus cavernosum in men with reduced arterial inflow. - Refractory erectile dysfunction: provides an alternative route of administration for patients who cannot use oral phosphodiesterase‑5 inhibitors.

Common Side Effects: - Penile pain or discomfort. - Urethral burning or stinging sensation. - Light vaginal bleeding or spotting. - Dizziness or mild headache. - Redness or erythema of the penis. - Minor urethral discharge.

Serious or Rare Side Effects: - Priapism lasting longer than four hours. - Severe hypotension or fainting. - Allergic reaction including rash, swelling, or anaphylaxis. - Penile fibrosis or scarring. - Significant urethral bleeding. - Local infection at the application site.

Before using Muse, consider the following precautions: - Medical evaluation: confirm diagnosis of erectile dysfunction prior to therapy. - Contraindications: avoid in patients with known hypersensitivity to alprostadil or any component of the formulation. - Cardiovascular risk: use with caution in men with unstable angina, recent myocardial infarction, or severe hypertension. - Bleeding disorders: assess risk of urethral bleeding in patients on anticoagulants or with coagulopathies. - Drug interactions: review concomitant medications that may affect blood pressure or hemostasis. - Store at room temperature: keep below 25 °C, retain in the original packaging, and protect from moisture and light.

Alprostadil may interact with several drug classes. Monitor patients closely and avoid certain combinations.

Major Interactions (Avoid): - Nitrates: concurrent use can cause severe hypotension. - Alpha‑blockers: additive blood‑pressure‑lowering effect may occur. - Anticoagulants: increased risk of urethral bleeding.

Moderate Interactions (Monitor Closely): - Antihypertensives: may enhance vasodilatory effects. - PDE‑5 inhibitors: combined use may raise the risk of priapism. - Alcohol: can potentiate vasodilatory responses and dizziness.