Muse (Alprostadil)

Alprostadil, the active ingredient in Muse, is a prostaglandin E1 analog presented as a urethral suppository for urethral administration. It facilitates erection by increasing blood flow to the corpus cavernosum and is prescribed for the treatment of erectile dysfunction in adult men.

GNH USA supplies Muse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across EU and global markets. The company provides reliable sourcing, batch traceability and compliance documentation for regulated distribution.

Alprostadil is a prostaglandin E1 analog used to manage erectile dysfunction by enhancing penile blood flow.

Erectile dysfunction (organic): improves erectile response in men with vascular causes. Erectile dysfunction (psychogenic): assists in achieving erection when psychological factors are present. Penile rehabilitation after radical prostatectomy: facilitates blood flow to support tissue recovery.

Alprostadil may cause a range of local and systemic adverse reactions.

Common Side Effects: - Urethral irritation: mild burning or discomfort at the site of administration. - Penile pain: transient aching during erection. - Erythema: redness of the urethral mucosa. - Headache: mild headache following dosing.

Serious or Rare Side Effects: - Priapism: prolonged erection lasting more than four hours requiring medical attention. - Hypotension: significant drop in blood pressure causing dizziness or fainting. - Allergic reaction: rash, swelling, or anaphylaxis in susceptible individuals.

When prescribing or handling Muse, several safety considerations should be observed. - Contraindication: avoid use in patients with known hypersensitivity to alprostadil or prostaglandin E1 analogs. - Cardiovascular risk: use cautiously in men with severe coronary artery disease or recent myocardial infarction. - Bleeding disorders: consider risk of increased bleeding in patients on anticoagulants. - Use in pediatric population: not indicated; safety not established. - Drug interactions: review concomitant medications for potential additive vasodilatory effects. - Store at room temperature: keep below 25°C, in original packaging, protected from moisture and light.

Alprostadil can interact with other agents that affect vascular tone or hemostasis.

Major Interactions (Avoid): - Nitrates: combined vasodilation may cause severe hypotension. - Alpha‑blockers: additive blood pressure lowering effect.

Moderate Interactions (Monitor Closely): - Anticoagulants/antiplatelet agents: increased risk of bleeding. - PDE5 inhibitors: may enhance erectile response and risk of priapism. - Sildenafil or other PDE5 inhibitors when used concurrently may require dose adjustment.