Multibic

Sodium hydrogen carbonate, magnesium chloride hexahydrate, sodium chloride and calcium chloride dihydrate, the active ingredients in Multibic, are an electrolyte solution presented as an intravenous solution for haemodialysis and renal replacement therapy use. It provides essential ions to support electrolyte balance and acid‑base status in patients undergoing dialysis.

GNH USA supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Multibic is employed in renal replacement therapy and dialysis to correct electrolyte and acid‑base disturbances. - Hemodialysis: maintains electrolyte and acid‑base balance during treatment. - Renal replacement therapy: supplies sodium, chloride, calcium, magnesium and bicarbonate to patients with renal failure. - Electrolyte replacement: corrects deficits of key ions during intravenous administration.

Multibic may be associated with a range of infusion‑related reactions.

Common Side Effects: - Mild hypernatremia: slight elevation of serum sodium. - Mild hypercalcemia: modest increase in calcium levels. - Infusion site irritation: redness or discomfort at the catheter site.

Serious or Rare Side Effects: - Severe hypermagnesemia: dangerous rise in magnesium concentration. - Anaphylactic reaction: acute allergic response requiring immediate treatment. - Cardiac arrhythmia: irregular heart rhythm linked to electrolyte imbalance.

When using Multibic, clinicians should observe several safety measures. - Monitor serum electrolytes: regularly check sodium, calcium, magnesium and bicarbonate levels. - Adjust infusion rate: tailor to the patient’s fluid balance and dialysis prescription. - Use caution in heart failure: excess sodium may worsen fluid overload. - Avoid in severe hypercalcemia or hypermagnesemia: risk of exacerbating electrolyte excess. - Store at ambient temperature: keep in original container, protect from light and moisture.

Multibic can interact with other agents that affect electrolyte balance.

Major Interactions (Avoid): - Calcium‑containing antacids: may cause hypercalcemia. - High‑dose magnesium supplements: increase risk of hypermagnesemia. - Concurrent sodium bicarbonate infusion: can lead to severe metabolic alkalosis.

Moderate Interactions (Monitor Closely): - Loop diuretics: may alter sodium and calcium excretion. - ACE inhibitors: affect sodium and potassium handling. - NSAIDs: can impair renal function and fluid status.