Multibic

Sodium Hydrogen Carbonate, the active ingredient in Multibic, is a dialysis solution presented as a solution for injection for haemodialysis and intravenous use. It provides electrolytes and buffering capacity to maintain acid‑base balance during haemodialysis in patients with renal failure.

GNH USA supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide.

Multibic is used in the dialysis and renal replacement therapy setting to manage electrolyte and acid‑base balance. - Haemodialysis: supports electrolyte homeostasis and buffering during the procedure. - Renal replacement therapy: supplies essential ions to patients undergoing chronic dialysis. - Acute kidney injury requiring dialysis: helps stabilize plasma chemistry while renal function recovers.

Multibic may be associated with infusion‑related reactions and electrolyte disturbances.

Common Side Effects: - Hypotension: transient drop in blood pressure during rapid infusion. - Mild electrolyte shifts: transient hypernatremia, hypomagnesemia or mild hyperkalemia. - Metabolic alkalosis: mild increase in blood pH after buffering. - Infusion site irritation: redness or discomfort at the catheter site.

Serious or Rare Side Effects: - Severe hyperkalemia: can precipitate cardiac arrhythmia. - Anaphylactic reaction: rare but may cause airway compromise. - Cardiac arrhythmia: associated with abrupt electrolyte changes. - Severe metabolic acidosis/alkalosis: extreme pH shifts requiring urgent correction.

When using Multibic, clinicians should observe several safety measures. - Assess electrolyte status: monitor serum Na+, K+, Mg2+ before and during infusion. - Adjust composition: tailor the solution based on individual patient laboratory values. - Avoid rapid infusion: limit infusion rate to prevent hypotension and sudden electrolyte shifts. - Use aseptic technique: ensure sterile handling to avoid contamination. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Multibic can interact with other agents that affect electrolyte balance.

Major Interactions (Avoid): - High‑dose potassium supplements: risk of dangerous hyperkalemia. - Calcium‑containing intravenous solutions: potential calcium overload.

Moderate Interactions (Monitor Closely): - Loop diuretics: may amplify electrolyte losses. - ACE inhibitors or ARBs: can increase serum potassium levels. - Beta‑blockers: may mask hypotensive responses during infusion.