GNH USA

Europe — EMA

Multibic

GNH USA supplies Multibic (Sodium hydrogen carbonate), a electrolyte solution for haemodialysis and intravenous electrolyte replacement.

Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc

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What is Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc?

Sodium hydrogen carbonate, the active ingredient in Multibic, is an electrolyte solution presented as a solution for injection for haemodialysis and intravenous use. Combined with magnesium chloride, potassium chloride, sodium chloride and calcium, it helps maintain acid‑base and electrolyte balance in patients undergoing dialysis or requiring intravenous electrolyte replacement.

GNH USA supplies Multibic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and dialysis clinics worldwide. The product meets EU quality standards and is distributed under strict regulatory oversight.

What is Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc used for?

Multibic is used as an electrolyte and buffering solution in renal replacement therapies and intravenous fluid management. - Haemodialysis: provides a dialysate composition that supports acid‑base balance and electrolyte homeostasis during dialysis sessions. - Intravenous electrolyte replacement: restores sodium, potassium, magnesium, calcium and chloride levels in patients receiving parenteral nutrition or fluid therapy. - Renal failure management: assists in maintaining plasma electrolyte concentrations in individuals with impaired kidney function.

What are the side effects of Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc?

Multibic may be associated with electrolyte‑related reactions and infusion site responses.

Common Side Effects: - Hypernatremia: elevated serum sodium levels. - Hyperkalemia: increased potassium concentration. - Hypermagnesemia: excess magnesium in blood. - Hypercalcemia: raised calcium levels. - Hypotension: drop in blood pressure during rapid infusion. - Infusion site irritation: redness or discomfort at the injection site.

Serious or Rare Side Effects: - Severe electrolyte imbalance leading to cardiac arrhythmia. - Metabolic alkalosis from excessive bicarbonate. - Pulmonary edema due to fluid overload. - Anaphylactic reaction: rare hypersensitivity response. - Acute coronary syndrome precipitated by rapid electrolyte shifts. - Severe hypertension from rapid sodium load.

What precautions apply to Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc?

When using Multibic, clinicians should observe the following precautions: - Monitor electrolytes: regularly check serum Na+, K+, Mg2+, Ca2+ and bicarbonate levels. - Adjust infusion rate: tailor the delivery speed to the patient’s cardiovascular status. - Cardiac disease: use cautiously in patients with known arrhythmias or heart failure. - Hyperkalemia: avoid in patients with markedly elevated potassium levels. - Hypermagnesemia: contraindicated in individuals with renal impairment causing magnesium accumulation. - Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

What does Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc interact with?

Multibic can interact with other medications that affect electrolyte balance or acid‑base status.

Major Interactions (Avoid): - Potassium‑sparing diuretics: may precipitate dangerous hyperkalemia. - Calcium channel blockers: can increase calcium load and risk of hypercalcemia. - Additional bicarbonate agents: may cause severe metabolic alkalosis.

Moderate Interactions (Monitor Closely): - Loop diuretics: may alter sodium and potassium levels, requiring closer monitoring. - ACE inhibitors or ARBs: can affect potassium balance. - NSAIDs: may impair renal function and modify electrolyte handling. - Antacids containing magnesium or calcium: increase total electrolyte exposure.

Frequently asked questions

What is Multibic used for?+
Multibic is an injectable electrolyte solution used during haemodialysis and for intravenous electrolyte replacement. It supplies sodium, potassium, magnesium, calcium and chloride, helping to maintain acid‑base balance and electrolyte homeostasis in patients with renal impairment or those receiving parenteral nutrition.
How does sodium hydrogen carbonate work in Multibic?+
Sodium hydrogen carbonate acts as a bicarbonate buffer, neutralising excess hydrogen ions and correcting metabolic acidosis. Together with the other electrolytes, it restores normal plasma concentrations, supports osmotic balance, and facilitates efficient removal of waste products during dialysis.
What is the usual dose of Multibic?+
The dose of Multibic is determined by the prescribing clinician based on the patient’s clinical condition, dialysis prescription or intravenous fluid requirements. Dosage is individualized and should follow the healthcare provider’s orders and institutional protocols.
Is Multibic safe to use during pregnancy or breastfeeding?+
Safety data for Multibic in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Multibic from GNH USA?+
To order Multibic, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Multibic compare with other dialysate solutions?+
Multibic offers a balanced composition of sodium hydrogen carbonate, magnesium, potassium, calcium and chloride, providing both buffering capacity and essential electrolytes. Compared with standard dialysate fluids that may lack magnesium or calcium, Multibic can reduce the need for supplemental electrolytes during treatment, but selection should be based on individual patient requirements and clinician preference.
What are the storage and handling requirements for Multibic?+
Multibic should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight and extreme temperatures. Do not freeze the solution, and inspect the vial for any particulate matter before use.
How is Multibic administered?+
Multibic is administered as a sterile solution for injection. During haemodialysis it is mixed with the dialysis circuit as the dialysate fluid. For intravenous use, it is infused through a controlled infusion set, following the prescribing clinician’s rate and volume instructions.
What are the most serious risks associated with Multibic?+
Serious risks include severe electrolyte disturbances such as hyperkalemia, hypermagnesemia or hypercalcemia, which can lead to cardiac arrhythmias, metabolic alkalosis, pulmonary edema, and rare anaphylactic reactions. Continuous monitoring of electrolyte levels and patient vital signs is essential to mitigate these risks.
Who should not use Multibic?+
Multibic should be avoided in patients with known hypersensitivity to any of its components, those with uncontrolled hyperkalemia, hypermagnesemia, or severe calcium overload, and individuals for whom rapid changes in plasma osmolarity could be hazardous, such as certain cardiac patients. Clinical judgment is required for each case.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Sodium Hydrogen Carbonate, Magnesium Chloride Hexahydrate, Potassium Chloride, Sodium Chloride, Calc
Route
Haemodialysis , Intravenous Use
Manufacturer
Fresenius Medical Care Deutschland Gmbh
Origin
EU