Mozartan (Losartan Potassium)

Losartan Potassium, the active ingredient in Mozartan, is an Angiotensin II receptor blocker (ARB) presented as a strength/form for oral use. It treats hypertension and related cardiovascular conditions in adults.

GNH USA supplies Mozartan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Losartan Potassium is an ARB that lowers blood pressure and protects target organs in several cardiovascular and renal conditions.

- Hypertension: reduces systolic and diastolic pressure, decreasing risk of stroke and myocardial infarction. - Heart failure: improves symptoms and survival by lowering after‑load. - Diabetic nephropathy: slows progression of renal impairment in patients with type 2 diabetes. - Stroke risk reduction in left ventricular hypertrophy: lowers incidence of cerebrovascular events in hypertensive patients with LVH.

Common Side Effects: - Dizziness: feeling light‑headed, especially after standing. - Headache: mild to moderate intensity. - Fatigue: general tiredness without exertion. - Nasal congestion: stuffy or runny nose. - Upper respiratory infection: mild cold‑like symptoms.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips, tongue, or throat requiring immediate medical attention. - Hyperkalemia: elevated serum potassium that can cause cardiac arrhythmias. - Acute renal impairment: sudden decrease in kidney function, especially when combined with other nephrotoxic agents. - Hepatic injury: abnormal liver enzymes or jaundice. - Severe hypotension: markedly low blood pressure leading to dizziness or fainting.

Before initiating therapy, clinicians should assess patient-specific factors and monitor relevant parameters.

- Blood pressure monitoring: ensure adequate control and avoid excessive hypotension. - Renal function assessment: check serum creatinine and eGFR periodically. - Serum potassium measurement: monitor for hyperkalemia, especially with potassium‑sparing agents. - Pregnancy avoidance: Losartan is contraindicated in pregnancy due to fetal toxicity. - Elderly caution: start at lower doses and monitor for orthostatic effects. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Losartan may interact with several medicines, requiring dose adjustments or avoidance.

Major Interactions (Avoid): - Aliskiren in diabetic patients: increased risk of renal dysfunction and hyperkalemia. - Concurrent ACE inhibitors or other ARBs: additive effect on potassium and renal function. - Potassium‑sparing diuretics (e.g., spironolactone): heightened hyperkalemia risk. - NSAIDs (e.g., ibuprofen): may blunt antihypertensive effect and impair renal perfusion.

Moderate Interactions (Monitor Closely): - Loop or thiazide diuretics: may enhance hypotensive response. - Lithium: losartan can raise lithium levels, risking toxicity. - CYP2C9 inhibitors (e.g., fluconazole): may increase losartan plasma concentrations. - Rifampin: may reduce losartan effectiveness by inducing metabolism.