Movicol

Macrogol 3350, the active ingredient in Movicol, is a osmotic laxative presented as a oral solution (powder for solution) for oral use. It treats constipation, faecal impaction and is used for bowel preparation prior to diagnostic procedures in adults and children as directed by a healthcare professional.

GNH USA supplies Movicol as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Movicol is an osmotic laxative indicated for conditions affecting bowel transit and stool consistency.

Constipation: softens stool and facilitates regular bowel movements. Faecal impaction: helps to break down hardened stool masses for easier evacuation. Bowel preparation prior to diagnostic procedures: clears the intestinal tract to improve visibility during endoscopic examinations.

Movicol may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Abdominal bloating: feeling of fullness or swelling in the abdomen. - Flatulence: increased intestinal gas. - Nausea: mild sensation of wanting to vomit. - Mild abdominal pain or cramps. - Diarrhoea: loose stools occurring more frequently. - Thirst: increased desire to drink fluids.

Serious or Rare Side Effects: - Severe electrolyte imbalance: abnormal levels of sodium, potassium or chloride. - Severe dehydration: significant loss of body water. - Allergic reactions: rash, itching, swelling, or difficulty breathing. - Severe abdominal pain: intense or persistent pain. - Rectal bleeding: visible blood in stool. - Acute renal failure: sudden loss of kidney function.

Before prescribing Movicol, clinicians should consider patient-specific factors and monitor for potential complications.

Assess renal function: evaluate kidney health to avoid accumulation of electrolytes. Monitor electrolytes: check serum sodium, potassium and chloride during prolonged use. Use with caution in the elderly: increased sensitivity to fluid shifts. Avoid in complete intestinal obstruction: risk of worsening blockage. Adjust dose in hepatic impairment: consider reduced clearance. Store at ambient temperature: keep in the original container, protect from moisture and heat.

Movicol can interact with other medications that affect fluid or electrolyte balance.

Major Interactions (Avoid): - Concomitant use with other osmotic laxatives: risk of excessive fluid loss. - Loop diuretics: may exacerbate electrolyte disturbances. - Lithium therapy: altered lithium plasma concentrations.

Moderate Interactions (Monitor Closely): - Anticholinergic agents: may reduce laxative efficacy. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): increased risk of renal impairment. - Calcium supplements: potential reduction in drug absorption.