GNH USA

Europe — EMA

Motilium Tropfen (Domperidone)

GNH USA supplies Motilium Tropfen (Domperidone), a dopamine D2 receptor antagonist for nausea, vomiting and gastroparesis. Request a quote for global supply.

Domperidone

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What is Domperidone?

Domperidone, the active ingredient in Motilium Tropfen, is a dopamine D2 receptor antagonist presented as an oral solution (drops) for oral use. It treats nausea, vomiting, gastroparesis and functional dyspepsia in adult patients. GNH USA supplies Motilium Tropfen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Domperidone used for?

Domperidone is employed to manage conditions linked to impaired gastrointestinal motility and nausea.

Nausea and vomiting: reduces the frequency and severity of nausea and vomiting episodes. Gastroparesis: enhances gastric emptying and alleviates associated symptoms such as early satiety and bloating. Functional dyspepsia: improves upper abdominal discomfort, fullness and post‑prandial distress.

What are the side effects of Domperidone?

Domperidone may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Dry mouth: reduced salivation leading to throat discomfort. - Abdominal cramps: intermittent stomach pain. - Headache: mild to moderate head pain. - Dizziness: sensation of light‑headedness. - Diarrhoea: loose stools. - Constipation: reduced bowel movements.

Serious or Rare Side Effects: - Cardiac arrhythmia: irregular heart rhythm, especially with QT‑prolonging drugs. - Extrapyramidal symptoms: involuntary muscle movements. - Galactorrhoea: unexpected milk production. - Severe allergic reactions: rash, swelling, or anaphylaxis. - Hyperprolactinaemia: elevated prolactin levels causing hormonal effects. - QT prolongation: potential for life‑threatening ventricular tachycardia.

What precautions apply to Domperidone?

Before prescribing Domperidone, clinicians should consider several safety aspects.

Assess cardiac risk: evaluate history of arrhythmia or prolonged QT interval. Monitor electrolytes: correct hypokalaemia or hypomagnesemia that may predispose to cardiac events. Use caution in hepatic impairment: dose adjustments may be required. Avoid in patients with prolactin‑dependent tumours: risk of tumour growth. Do not co‑administer with strong CYP3A4 inhibitors: may increase plasma concentrations. Store at room temperature: keep in the original container, protect from moisture and light.

What does Domperidone interact with?

Domperidone can interact with other medicines, altering its safety profile.

Major Interactions (Avoid): - Quinidine: additive QT‑prolongation risk. - Ketoconazole: strong CYP3A4 inhibition raises domperidone levels. - Erythromycin: similar CYP3A4 inhibition effect. - Other QT‑prolonging agents: combined risk of cardiac arrhythmias.

Moderate Interactions (Monitor Closely): - Anticholinergics: may reduce gastrointestinal motility benefits. - Other antiemetics: potential for overlapping side effects. - Drugs metabolised by CYP3A4: monitor for altered plasma concentrations.

Frequently asked questions

What is Motilium Tropfen used for?+
Motilium Tropfen contains domperidone, an antiemetic and gastro‑prokinetic agent. It is prescribed to relieve nausea and vomiting, to improve gastric emptying in gastroparesis, and to alleviate symptoms of functional dyspepsia such as early satiety and upper abdominal discomfort.
How does domperidone work in Motilium Tropfen?+
Domperidone blocks peripheral dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal smooth muscle. This action reduces nausea signalling to the brain and enhances motility of the stomach and intestines, promoting faster gastric emptying without significant central nervous system effects.
What is the usual dose of Motilium Tropfen?+
The appropriate dose of Motilium Tropfen is determined by the prescribing healthcare professional based on the patient’s condition, age, renal and hepatic function, and concomitant medications. Patients should follow the exact dosing instructions provided by their prescriber.
Is Motilium Tropfen safe during pregnancy or breastfeeding?+
Safety data for domperidone in pregnancy and lactation are limited, and the product is not classified in a specific pregnancy category. Healthcare providers should weigh potential benefits against possible risks before prescribing to pregnant or nursing women.
How do I order Motilium Tropfen from GNH USA?+
To request Motilium Tropfen, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Motilium Tropfen compare with other antiemetics?+
Compared with centrally acting antiemetics such as metoclopramide, domperidone has limited penetration of the blood‑brain barrier, resulting in fewer central nervous system side effects. However, both agents share dopamine antagonism and may require similar cardiac monitoring when used with QT‑prolonging drugs.
What are the storage and handling requirements for Motilium Tropfen?+
Motilium Tropfen should be stored at room temperature, below 25 °C, in its original tightly sealed container. Protect the solution from moisture, direct sunlight and extreme temperature fluctuations to maintain stability and potency.
How is Motilium Tropfen administered?+
Motilium Tropfen is an oral solution administered as drops. The prescriber will specify the exact volume to be taken, typically measured with a calibrated dropper, and the frequency of dosing, which may be before meals or as directed.
What are the most serious risks associated with Motilium Tropfen?+
The most serious risks include cardiac arrhythmias such as QT‑interval prolongation, especially when combined with other QT‑prolonging agents, and rare extrapyramidal reactions. Patients with known heart disease, electrolyte disturbances, or those taking strong CYP3A4 inhibitors should be monitored closely.
Who should not use Motilium Tropfen?+
Motilium Tropfen is contraindicated in individuals with known hypersensitivity to domperidone, those with prolactin‑dependent tumours, and patients taking other medications that significantly prolong the QT interval. It should also be avoided in patients with severe hepatic impairment unless specifically advised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Domperidone
Route
Oral Use
Manufacturer
Cheplapharm Arzneimittel Gmbh
Origin
EU

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