Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is used to relieve nausea, vomiting, gastroparesis and functional dyspepsia in adult patients. GNH USA supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Motilium acts on the gastrointestinal motility pathway and is indicated for several digestive disorders. - Nausea and vomiting: reduces episodes of acute and chronic nausea and vomiting. - Gastroparesis: improves gastric emptying and alleviates related symptoms. - Functional dyspepsia: relieves upper abdominal discomfort and early satiety.

Domperidone is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects: - Dry mouth: reduced salivary flow causing throat discomfort. - Headache: mild to moderate intensity. - Abdominal cramps: intermittent stomach discomfort. - Dizziness: transient light‑headedness. - Diarrhoea: loose stools occurring occasionally. - Constipation: reduced bowel movements.

Serious or Rare Side Effects: - Cardiac arrhythmia: QT interval prolongation leading to potential ventricular tachycardia. - Severe allergic reactions: rash, itching, swelling, or anaphylaxis. - Extrapyramidal symptoms: involuntary muscle movements. - Hyperprolactinaemia: elevated prolactin causing galactorrhoea. - Neuroleptic malignant syndrome: rare but life‑threatening condition. - Hepatic dysfunction: abnormal liver enzymes.

Before prescribing Domperidone, clinicians should consider several safety aspects. - Cardiac risk assessment: evaluate history of arrhythmia or prolonged QT interval. - Concomitant QT‑prolonging drugs: avoid or monitor closely when used together. - Electrolyte monitoring: correct hypokalaemia or hypomagnesaemia. - Hepatic impairment: use with caution in patients with liver dysfunction. - Hypersensitivity: discontinue if allergic reactions occur. - Store at below 25°C: keep in the original pack, protect from moisture.

Domperidone may interact with other medicines, requiring attention to the interaction level.

Major Interactions (Avoid): - Antiarrhythmic agents (e.g., quinidine): increase risk of cardiac arrhythmias. - Macrolide antibiotics (e.g., erythromycin): potentiate QT prolongation. - Ketoconazole: strong CYP3A4 inhibition raising domperidone levels. - HIV protease inhibitors: elevate plasma concentrations. - Other QT‑prolonging drugs: additive effect on cardiac conduction.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inhibitors (e.g., fluconazole): may modestly increase exposure. - Anticholinergic agents: could enhance gastrointestinal side effects. - Other dopamine antagonists: potential additive central effects.