Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine antagonist presented as an oral tablet for oral use. It is used to relieve nausea, vomiting, gastroparesis, functional dyspepsia and gastro‑oesophageal reflux disease in adults. GNH USA supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Domperidone acts as a prokinetic agent that improves gastrointestinal motility, addressing several related conditions. - Nausea and vomiting: reduces episodes by enhancing gastric emptying. - Gastroparesis: improves stomach emptying and symptom relief. - Functional dyspepsia: alleviates discomfort and early satiety. - Gastro‑oesophageal reflux disease: decreases reflux episodes by promoting gastric clearance.

Domperidone may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Dry mouth: mild reduction in salivary flow. - Headache: occasional tension‑type headache. - Abdominal cramps: mild gastrointestinal discomfort. - Diarrhoea: loose stools in some patients.

Serious or Rare Side Effects: - Cardiac arrhythmia: potential QT‑interval prolongation. - Extrapyramidal symptoms: rare movement disorders. - Hyperprolactinaemia: elevated prolactin levels causing galactorrhoea.

When prescribing Domperidone, consider the following safety measures. - Cardiac monitoring: avoid use in patients with known QT prolongation. - Drug interactions: review concomitant medications that affect cardiac rhythm. - Liver function: use caution in patients with hepatic impairment. - Pregnancy and lactation: assess risk‑benefit as safety data are limited. - Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Domperidone can interact with several medicines, altering its safety profile.

Major Interactions (Avoid): - Macrolide antibiotics (e.g., erythromycin): increase risk of cardiac arrhythmia. - Antifungal agents (e.g., ketoconazole): potentiate QT prolongation.

Moderate Interactions (Monitor Closely): - Antidepressants (e.g., citalopram): may modestly affect cardiac conduction. - Antihistamines (e.g., diphenhydramine): can enhance central nervous system effects. - Anticholinergic drugs: may reduce gastrointestinal motility benefits.