Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral tablet for oral use. It is employed to relieve nausea and vomiting, improve gastric emptying in gastroparesis, and manage functional dyspepsia in adult patients who require prokinetic therapy. GNH USA supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics, and research institutions across multiple regions. Our distribution network ensures regulatory compliance, quality assurance, and timely delivery to meet the therapeutic needs of patients globally.

Domperidone is used to treat gastrointestinal motility disorders and associated nausea. - Nausea and vomiting: Reduces episodes by blocking peripheral dopamine receptors in the chemoreceptor trigger zone. - Gastroparesis: Improves gastric emptying and relieves symptoms of delayed stomach emptying. - Functional dyspepsia: Alleviates upper abdominal discomfort and fullness by enhancing gastric motility. - Post‑operative nausea: Prevents nausea after surgical procedures by antagonizing dopamine pathways.

Domperidone may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Dry mouth: Reduced salivary secretion leading to throat discomfort. - Abdominal cramps: Mild gastrointestinal discomfort or spasm. - Diarrhea: Increased bowel movements with loose stools. - Headache: Transient mild to moderate head pain. - Drowsiness: Slight sedation or fatigue.

Serious or Rare Side Effects: - Cardiac arrhythmia: Irregular heart rhythm, potentially serious. - Extrapyramidal symptoms: Involuntary muscle movements or tremor. - Hyperprolactinemia: Elevated prolactin levels causing galactorrhea. - Severe allergic reaction: Rash, itching, swelling, or anaphylaxis.

When prescribing domperidone, clinicians should consider several precautionary measures to ensure patient safety. - Cardiac risk assessment: Evaluate patients for existing heart disease or prolonged QT interval before use. - Electrolyte monitoring: Check serum potassium and magnesium levels, especially in patients on diuretics. - Liver function review: Adjust use in patients with hepatic impairment. - Age limitation: Use with caution in elderly patients due to increased sensitivity. - Drug interaction vigilance: Review concomitant medications that may prolong QT interval. - Store at ambient temperature: Keep tablets below 25°C in the original container, protected from moisture.

Domperidone can interact with other medicines, affecting its safety and efficacy.

Major Interactions (Avoid): - QT‑prolonging agents: Co‑administration with drugs such as macrolide antibiotics or antiarrhythmics may increase risk of serious cardiac arrhythmias. - CYP3A4 inhibitors: Strong inhibitors like ketoconazole can raise domperidone plasma levels, heightening toxicity risk.

Moderate Interactions (Monitor Closely): - Anticholinergics: May reduce gastrointestinal motility benefits of domperidone. - Other dopamine antagonists: Combined effect can enhance extrapyramidal side effects. - Proton pump inhibitors: May slightly alter domperidone absorption.