Motilium (Domperidone)

Domperidone, the active ingredient in Motilium, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is used to alleviate nausea, vomiting, and to improve gastric motility in adults and related functional dyspepsia symptoms.

GNH USA supplies Motilium as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Domperidone acts on peripheral dopamine receptors to reduce nausea and enhance gastrointestinal motility, making it useful for several gastrointestinal conditions.

- Nausea and vomiting: Reduces frequency and severity of symptoms associated with various causes. - Gastroparesis: Improves gastric emptying and relieves related discomfort. - Functional dyspepsia: Alleviates upper abdominal pain and early satiety by enhancing motility.

Domperidone may cause a range of adverse reactions, which are generally classified by frequency and severity.

Common Side Effects: - Dry mouth: Reduced salivation leading to a feeling of thirst. - Abdominal cramps: Mild to moderate discomfort in the stomach area. - Diarrhea: Increased frequency of loose stools. - Headache: Transient mild to moderate head pain. - Dizziness: Light‑headed sensation, especially when standing quickly.

Serious or Rare Side Effects: - Cardiac arrhythmia: Irregular heart rhythm that may require medical attention. - Extrapyramidal symptoms: Uncontrolled muscle movements, though rare with peripheral action. - Hyperprolactinemia: Elevated prolactin levels causing galactorrhea or menstrual changes. - Severe allergic reaction: Rash, itching, swelling, or difficulty breathing.

Before prescribing Domperidone, clinicians should consider several safety precautions to minimize risk.

- Cardiac assessment: Evaluate QT interval and avoid use in patients with known arrhythmias. - Liver function: Monitor hepatic enzymes, especially in patients with hepatic impairment. - Concomitant medications: Review drugs that also prolong QT interval. - Pregnancy and lactation: Use only if potential benefit outweighs risk, as safety data are limited. - Age considerations: Adjust use cautiously in elderly patients due to increased sensitivity. - Store at ambient temperature: Keep below 25 °C in the original packaging, protected from moisture.

Domperidone can interact with other medicines, influencing its safety and effectiveness.

Major Interactions (Avoid): - Antifungal azoles (e.g., ketoconazole): Increase domperidone plasma levels, raising risk of cardiac toxicity. - Macrolide antibiotics (e.g., erythromycin): Similar effect on metabolism leading to elevated concentrations. - Certain antiarrhythmics (e.g., quinidine): Additive QT‑prolongation risk.

Moderate Interactions (Monitor Closely): - CYP3A4 inhibitors (e.g., clarithromycin, ritonavir): May require dose adjustment or ECG monitoring. - Antidepressants that affect QT interval (e.g., citalopram): Monitor cardiac rhythm. - Anticholinergic agents: May diminish pro‑kinetic benefit.