GNH USA

Europe — EMA

Motilex (Clebopride Hydrogen Maleate)

GNH USA supplies Motilex (Clebopride Hydrogen Maleate), a dopamine D2 antagonist for dyspepsia, GERD and nausea. Request a quote for worldwide supply.

Clebopride Hydrogen Maleate

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What is Clebopride Hydrogen Maleate?

Clebopride hydrogen maleate, the active ingredient in Motilex, is a dopamine D2 receptor antagonist presented as an oral dosage form for oral use. It is employed to improve gastrointestinal motility in patients with functional dyspepsia, gastro‑oesophageal reflux disease and nausea or vomiting.

GNH USA supplies Motilex as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Clebopride Hydrogen Maleate used for?

Motilex acts on dopamine D2 receptors in the gastrointestinal tract to enhance motility and aid gastric emptying.

- Functional dyspepsia: reduces post‑prandial fullness and upper abdominal discomfort. - Gastro‑oesophageal reflux disease (GERD): improves lower oesophageal sphincter tone and reduces reflux episodes. - Nausea and vomiting: accelerates gastric emptying, helping to control acute and chronic nausea.

What are the side effects of Clebopride Hydrogen Maleate?

Motilex may be associated with a range of adverse reactions.

Common Side Effects: - Dizziness: transient light‑headedness, especially after the first dose. - Dry mouth: reduced salivary flow, often mild. - Constipation: decreased bowel movements. - Headache: mild to moderate intensity. - Somnolence: feeling unusually sleepy. - Nausea: occasional upset stomach.

Serious or Rare Side Effects: - Extrapyramidal symptoms: involuntary muscle movements or rigidity. - Cardiac arrhythmia: irregular heart rhythm, rarely reported. - Severe hypotension: marked drop in blood pressure. - Neuroleptic malignant syndrome: life‑threatening reaction with fever and muscle rigidity. - Hepatic dysfunction: elevated liver enzymes. - Allergic reactions: rash, pruritus, or anaphylaxis.

What precautions apply to Clebopride Hydrogen Maleate?

Before prescribing Motilex, clinicians should consider several safety aspects.

- Renal or hepatic impairment: adjust monitoring as drug clearance may be reduced. - Bowel obstruction: avoid use in patients with known mechanical obstruction. - Concomitant anticholinergics: increased risk of dry mouth and constipation. - Elderly patients: start at lower doses and monitor for dizziness. - Pregnancy and lactation: use only if potential benefit justifies potential risk. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

What does Clebopride Hydrogen Maleate interact with?

Motilex can interact with other medicines that affect dopamine pathways or gastrointestinal motility.

Major Interactions (Avoid): - Other dopamine antagonists (e.g., antipsychotics): may potentiate extrapyramidal effects. - Strong CYP3A4 inhibitors: can increase plasma concentrations.

Moderate Interactions (Monitor Closely): - Anticholinergic agents: may exacerbate dry mouth and constipation. - Prokinetic agents (e.g., metoclopramide): additive effects on motility could cause diarrhea. - Antihypertensives: monitor blood pressure for additive hypotensive effect.

Frequently asked questions

What conditions is Motilex used to treat?+
Motilex is prescribed to manage functional dyspepsia, gastro‑oesophageal reflux disease (GERD), and nausea or vomiting. By enhancing gastrointestinal motility, it helps relieve upper‑abdominal discomfort, reduces reflux episodes, and accelerates gastric emptying in affected patients.
How does clebopride hydrogen maleate work in the body?+
Clebopride hydrogen maleate blocks dopamine D2 receptors in the gut wall. This antagonism lifts dopamine‑mediated inhibition of smooth‑muscle activity, increasing cholinergic stimulation, promoting coordinated peristalsis, and speeding up gastric emptying, which improves digestive symptoms.
What is the usual dose of Motilex?+
The specific dose and dosing schedule of Motilex are determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.
Is Motilex safe to use during pregnancy or while breastfeeding?+
Safety data for clebopride hydrogen maleate in pregnancy and lactation are limited. It should only be used if the potential therapeutic benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Motilex from GNH USA?+
To request Motilex, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Motilex compare with other prokinetic agents?+
Motilex, as a dopamine D2 antagonist, differs from agents such as metoclopramide (a dopamine‑serotonin antagonist) or erythromycin (a motilin receptor agonist). Its selective D2 blockade offers a distinct mechanism that may be preferred when other prokinetics are contraindicated or have caused intolerable side effects.
What are the recommended storage conditions for Motilex?+
Motilex should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Motilex administered to patients?+
Motilex is taken orally, usually with a glass of water. The exact timing relative to meals and the frequency of administration are determined by the prescribing clinician, who will provide detailed instructions tailored to the individual’s therapeutic needs.
What are the most serious risks associated with Motilex?+
Serious adverse reactions, although rare, can include extrapyramidal symptoms, severe hypotension, cardiac arrhythmias, neuroleptic malignant syndrome, and significant hepatic dysfunction. Patients should be monitored closely for any of these signs, and therapy should be discontinued if they occur.
Who should not use Motilex?+
Motilex is contraindicated in patients with known mechanical bowel obstruction, severe hepatic impairment, or a history of hypersensitivity to clebopride or any of its excipients. Caution is also advised for individuals taking other dopamine antagonists or those with uncontrolled cardiovascular disease.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Clebopride Hydrogen Maleate
Route
Oral Use
Manufacturer
Almirall, S.A.
Origin
EU

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